The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance

Changes in dopaminergic neuromodulation play a key role in adult memory decline. Recent research has also implicated noradrenaline in shaping late-life memory. However, it is unclear whether these two neuromodulators have distinct roles in age-related cognitive changes. Here, combining longitudinal...

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Autores principales: Dahl, Martin J., Bachman, Shelby L., Dutt, Shubir, Düzel, Sandra, Bodammer, Nils C., Lindenberger, Ulman, Kühn, Simone, Werkle-Bergner, Markus, Mather, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501910/
https://www.ncbi.nlm.nih.gov/pubmed/37653256
http://dx.doi.org/10.1038/s43587-023-00469-z
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author Dahl, Martin J.
Bachman, Shelby L.
Dutt, Shubir
Düzel, Sandra
Bodammer, Nils C.
Lindenberger, Ulman
Kühn, Simone
Werkle-Bergner, Markus
Mather, Mara
author_facet Dahl, Martin J.
Bachman, Shelby L.
Dutt, Shubir
Düzel, Sandra
Bodammer, Nils C.
Lindenberger, Ulman
Kühn, Simone
Werkle-Bergner, Markus
Mather, Mara
author_sort Dahl, Martin J.
collection PubMed
description Changes in dopaminergic neuromodulation play a key role in adult memory decline. Recent research has also implicated noradrenaline in shaping late-life memory. However, it is unclear whether these two neuromodulators have distinct roles in age-related cognitive changes. Here, combining longitudinal MRI of the dopaminergic substantia nigra–ventral tegmental area (SN-VTA) and noradrenergic locus coeruleus (LC) in younger (n = 69) and older (n = 251) adults, we found that dopaminergic and noradrenergic integrity are differentially associated with memory performance. While LC integrity was related to better episodic memory across several tasks, SN-VTA integrity was linked to working memory. Longitudinally, we found that older age was associated with more negative change in SN-VTA and LC integrity. Notably, changes in LC integrity reliably predicted future episodic memory. These differential associations of dopaminergic and noradrenergic nuclei with late-life cognitive decline have potential clinical utility, given their degeneration in several age-associated diseases.
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spelling pubmed-105019102023-09-16 The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance Dahl, Martin J. Bachman, Shelby L. Dutt, Shubir Düzel, Sandra Bodammer, Nils C. Lindenberger, Ulman Kühn, Simone Werkle-Bergner, Markus Mather, Mara Nat Aging Article Changes in dopaminergic neuromodulation play a key role in adult memory decline. Recent research has also implicated noradrenaline in shaping late-life memory. However, it is unclear whether these two neuromodulators have distinct roles in age-related cognitive changes. Here, combining longitudinal MRI of the dopaminergic substantia nigra–ventral tegmental area (SN-VTA) and noradrenergic locus coeruleus (LC) in younger (n = 69) and older (n = 251) adults, we found that dopaminergic and noradrenergic integrity are differentially associated with memory performance. While LC integrity was related to better episodic memory across several tasks, SN-VTA integrity was linked to working memory. Longitudinally, we found that older age was associated with more negative change in SN-VTA and LC integrity. Notably, changes in LC integrity reliably predicted future episodic memory. These differential associations of dopaminergic and noradrenergic nuclei with late-life cognitive decline have potential clinical utility, given their degeneration in several age-associated diseases. Nature Publishing Group US 2023-08-31 2023 /pmc/articles/PMC10501910/ /pubmed/37653256 http://dx.doi.org/10.1038/s43587-023-00469-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Dahl, Martin J.
Bachman, Shelby L.
Dutt, Shubir
Düzel, Sandra
Bodammer, Nils C.
Lindenberger, Ulman
Kühn, Simone
Werkle-Bergner, Markus
Mather, Mara
The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
title The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
title_full The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
title_fullStr The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
title_full_unstemmed The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
title_short The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
title_sort integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501910/
https://www.ncbi.nlm.nih.gov/pubmed/37653256
http://dx.doi.org/10.1038/s43587-023-00469-z
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