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The prevalence and outcomes of depression in older HIV-positive adults in Northern Tanzania: a longitudinal study

Studies of depression and its outcomes in older people living with HIV (PLWH) are currently lacking in sub-Saharan Africa. This study aims to investigate the prevalence of psychiatric disorders in PLWH aged ≥ 50 years in Tanzania focussing on prevalence and 2-year outcomes of depression. PLWH aged ≥...

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Detalles Bibliográficos
Autores principales: Dua, Damneek, Stubbs, Oliver, Urasa, Sarah, Rogathe, Jane, Duijinmaijer, Ashanti, Howlett, William, Dekker, Marieke, Kisoli, Aloyce, Mukaetova-Ladinska, Elizabeta B., Gray, William K., Lewis, Thomas, Walker, Richard W., Dotchin, Catherine L., Lwezuala, Bingileki, Makupa, Philip C., Paddick, Stella Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501928/
https://www.ncbi.nlm.nih.gov/pubmed/37227670
http://dx.doi.org/10.1007/s13365-023-01140-4
Descripción
Sumario:Studies of depression and its outcomes in older people living with HIV (PLWH) are currently lacking in sub-Saharan Africa. This study aims to investigate the prevalence of psychiatric disorders in PLWH aged ≥ 50 years in Tanzania focussing on prevalence and 2-year outcomes of depression. PLWH aged ≥ 50 were systematically recruited from an outpatient clinic and assessed using the Mini-International Neuropsychiatric Interview (MINI). Neurological and functional impairment was assessed at year 2 follow-up. At baseline, 253 PLWH were recruited (72.3% female, median age 57, 95.5% on cART). DSM-IV depression was highly prevalent (20.9%), whereas other DSM-IV psychiatric disorders were uncommon. At follow-up (n = 162), incident cases of DSM-IV depression decreased from14.2 to 11.1% (χ(2): 2.48, p = 0.29); this decline was not significant. Baseline depression was associated with increased functional and neurological impairment. At follow-up, depression was associated with negative life events (p = 0.001), neurological impairment (p < 0.001), and increased functional impairment (p = 0.018), but not with HIV and sociodemographic factors. In this setting, depression appears highly prevalent and associated with poorer neurological and functional outcomes and negative life events. Depression may be a future intervention target. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13365-023-01140-4.