A pan-sarcoma landscape of telomeric content shows that alterations in RAD51B and GID4 are associated with higher telomeric content

Tumor cells need to activate a telomere maintenance mechanism, enabling limitless replication. The bulk of evidence supports that sarcomas predominantly use alternative lengthening of telomeres (ALT) mechanism, commonly associated with alterations in ATRX and DAXX. In our dataset, only 12.3% of sarc...

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Detalles Bibliográficos
Autores principales: Sharaf, Radwa, Jin, Dexter X., Grady, John, Napier, Christine, Ebot, Ericka, Frampton, Garrett M., Albacker, Lee A., Thomas, David M., Montesion, Meagan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502097/
https://www.ncbi.nlm.nih.gov/pubmed/37709802
http://dx.doi.org/10.1038/s41525-023-00369-6

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