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Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion
Brachial plexus nerve root avulsion results from complete separation of the nerve root from the spinal cord and is one of the most challenging types of neuropathic pain, coinciding with motor, sensory and autonomic deficits. The severe pain and typical impossibility of root reattachment often leads...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502345/ https://www.ncbi.nlm.nih.gov/pubmed/37720911 http://dx.doi.org/10.3389/fpain.2023.1256396 |
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author | Dickinson, Jonathan E. Inzunza, Jose Adalberto Dominguez Perez-Villa, Liliana Millar, Trevor G. Pushparaj, Abhiram P. |
author_facet | Dickinson, Jonathan E. Inzunza, Jose Adalberto Dominguez Perez-Villa, Liliana Millar, Trevor G. Pushparaj, Abhiram P. |
author_sort | Dickinson, Jonathan E. |
collection | PubMed |
description | Brachial plexus nerve root avulsion results from complete separation of the nerve root from the spinal cord and is one of the most challenging types of neuropathic pain, coinciding with motor, sensory and autonomic deficits. The severe pain and typical impossibility of root reattachment often leads to requests for amputation. Ibogaine is an indole alkaloid producing psychoactive effects through reported actions upon multiple neurotransmitter systems, including NMDA, κ- and µ-opioid receptors and σ(2) receptor sites, along with stimulation of neurotrophic factors GDNF and BDNF. In this case report we describe a 53-year-old male with two decades of severe intractable pain due to brachial plexus nerve root avulsion from vehicular trauma who was successfully treated with both high dose inpatient and low dose outpatient administrations of ibogaine. Though promising for future study, the adverse effects of high dose ibogaine administrations may limit tolerability of this saturation protocol to the most refractory cases. |
format | Online Article Text |
id | pubmed-10502345 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105023452023-09-16 Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion Dickinson, Jonathan E. Inzunza, Jose Adalberto Dominguez Perez-Villa, Liliana Millar, Trevor G. Pushparaj, Abhiram P. Front Pain Res (Lausanne) Pain Research Brachial plexus nerve root avulsion results from complete separation of the nerve root from the spinal cord and is one of the most challenging types of neuropathic pain, coinciding with motor, sensory and autonomic deficits. The severe pain and typical impossibility of root reattachment often leads to requests for amputation. Ibogaine is an indole alkaloid producing psychoactive effects through reported actions upon multiple neurotransmitter systems, including NMDA, κ- and µ-opioid receptors and σ(2) receptor sites, along with stimulation of neurotrophic factors GDNF and BDNF. In this case report we describe a 53-year-old male with two decades of severe intractable pain due to brachial plexus nerve root avulsion from vehicular trauma who was successfully treated with both high dose inpatient and low dose outpatient administrations of ibogaine. Though promising for future study, the adverse effects of high dose ibogaine administrations may limit tolerability of this saturation protocol to the most refractory cases. Frontiers Media S.A. 2023-09-01 /pmc/articles/PMC10502345/ /pubmed/37720911 http://dx.doi.org/10.3389/fpain.2023.1256396 Text en © 2023 Dickinson, Inunza, Perez-Villa, Millar and Pushparaj. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pain Research Dickinson, Jonathan E. Inzunza, Jose Adalberto Dominguez Perez-Villa, Liliana Millar, Trevor G. Pushparaj, Abhiram P. Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion |
title | Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion |
title_full | Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion |
title_fullStr | Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion |
title_full_unstemmed | Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion |
title_short | Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion |
title_sort | case report: ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion |
topic | Pain Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502345/ https://www.ncbi.nlm.nih.gov/pubmed/37720911 http://dx.doi.org/10.3389/fpain.2023.1256396 |
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