Cleavage fragments of the C-terminal tail of polycystin-1 are regulated by oxidative stress and induce mitochondrial dysfunction

Mutations in the gene encoding polycystin-1 (PC1) are the most common cause of autosomal dominant polycystic kidney disease (ADPKD). Cysts in ADPKD exhibit a Warburg-like metabolism characterized by dysfunctional mitochondria and aerobic glycolysis. PC1 is an integral membrane protein with a large e...

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Detalles Bibliográficos
Autores principales: Pellegrini, Hannah, Sharpe, Elizabeth H., Liu, Guangyi, Nishiuchi, Eiko, Doerr, Nicholas, Kipp, Kevin R., Chin, Tiffany, Schimmel, Margaret F., Weimbs, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502374/
https://www.ncbi.nlm.nih.gov/pubmed/37579949
http://dx.doi.org/10.1016/j.jbc.2023.105158

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