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Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset
The cochlea consists of diverse cellular populations working in harmony to convert mechanical stimuli into electrical signals for the perception of sound. Otic mesenchyme cells (OMCs), often considered a homogeneous cell type, are essential for normal cochlear development and hearing. Despite being...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502415/ https://www.ncbi.nlm.nih.gov/pubmed/37720106 http://dx.doi.org/10.1016/j.isci.2023.107769 |
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author | Rose, Kevin P. Manilla, Gabriella Milon, Beatrice Zalzman, Ori Song, Yang Coate, Thomas M. Hertzano, Ronna |
author_facet | Rose, Kevin P. Manilla, Gabriella Milon, Beatrice Zalzman, Ori Song, Yang Coate, Thomas M. Hertzano, Ronna |
author_sort | Rose, Kevin P. |
collection | PubMed |
description | The cochlea consists of diverse cellular populations working in harmony to convert mechanical stimuli into electrical signals for the perception of sound. Otic mesenchyme cells (OMCs), often considered a homogeneous cell type, are essential for normal cochlear development and hearing. Despite being the most numerous cell type in the developing cochlea, OMCs are poorly understood. OMCs are known to differentiate into spatially and functionally distinct cell types, including fibrocytes of the lateral wall and spiral limbus, modiolar osteoblasts, and specialized tympanic border cells of the basilar membrane. Here, we show that OMCs are transcriptionally and functionally heterogeneous and can be divided into four distinct populations that spatially correspond to OMC-derived cochlear structures. We also show that this heterogeneity and complexity of OMCs commences during early phases of cochlear development. Finally, we describe the cell-cell communication network of the developing cochlea, inferring a major role for OMC in outgoing signaling. |
format | Online Article Text |
id | pubmed-10502415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105024152023-09-16 Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset Rose, Kevin P. Manilla, Gabriella Milon, Beatrice Zalzman, Ori Song, Yang Coate, Thomas M. Hertzano, Ronna iScience Article The cochlea consists of diverse cellular populations working in harmony to convert mechanical stimuli into electrical signals for the perception of sound. Otic mesenchyme cells (OMCs), often considered a homogeneous cell type, are essential for normal cochlear development and hearing. Despite being the most numerous cell type in the developing cochlea, OMCs are poorly understood. OMCs are known to differentiate into spatially and functionally distinct cell types, including fibrocytes of the lateral wall and spiral limbus, modiolar osteoblasts, and specialized tympanic border cells of the basilar membrane. Here, we show that OMCs are transcriptionally and functionally heterogeneous and can be divided into four distinct populations that spatially correspond to OMC-derived cochlear structures. We also show that this heterogeneity and complexity of OMCs commences during early phases of cochlear development. Finally, we describe the cell-cell communication network of the developing cochlea, inferring a major role for OMC in outgoing signaling. Elsevier 2023-08-29 /pmc/articles/PMC10502415/ /pubmed/37720106 http://dx.doi.org/10.1016/j.isci.2023.107769 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Rose, Kevin P. Manilla, Gabriella Milon, Beatrice Zalzman, Ori Song, Yang Coate, Thomas M. Hertzano, Ronna Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset |
title | Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset |
title_full | Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset |
title_fullStr | Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset |
title_full_unstemmed | Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset |
title_short | Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset |
title_sort | spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502415/ https://www.ncbi.nlm.nih.gov/pubmed/37720106 http://dx.doi.org/10.1016/j.isci.2023.107769 |
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