A Phase I, Multicenter, Open-Label, First-in-Human Study of DS-6157a in Patients with Advanced Gastrointestinal Stromal Tumor

PURPOSE: To evaluate DS-6157a, an antibody–drug conjugate targeting G protein–coupled receptor 20 (GPR20), in gastrointestinal stromal tumors (GIST). PATIENTS AND METHODS: In this phase I multicenter, open-label, multiple-dose study, patients with previously treated advanced GIST received intravenou...

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Detalles Bibliográficos
Autores principales: George, Suzanne, Heinrich, Michael C., Somaiah, Neeta, Oppelt, Peter, McLeod, Robert, Nishioka, Satoshi, Kundu, Madan G., Qian, Xiaozhong, Kumar, Prasanna, Laadem, Abderrahmane, Lau, Yvonne, Tran, Brittany P., Fallon, Maura, Dosunmu, Ololade, Shi, Julia, Naito, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Clinical Trials: Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502450/
https://www.ncbi.nlm.nih.gov/pubmed/37363962
http://dx.doi.org/10.1158/1078-0432.CCR-23-0640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502450/
https://www.ncbi.nlm.nih.gov/pubmed/37363962
http://dx.doi.org/10.1158/1078-0432.CCR-23-0640

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