Trackable Intratumor Microdosing and Spatial Profiling Provide Early Insights into Activity of Investigational Agents in the Intact Tumor Microenvironment

PURPOSE: Cancer drug development is currently limited by a paradigm of preclinical evaluation that does not adequately recapitulate the complexity of the intact human tumor microenvironment (TME). To overcome this, we combined trackable intratumor microdosing (CIVO) with spatial biology readouts to...

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Detalles Bibliográficos
Autores principales: Derry, Jonathan M.J., Burns, Connor, Frazier, Jason P., Beirne, Emily, Grenley, Marc, DuFort, Christopher C., Killingbeck, Emily, Leon, Michael, Williams, Claire, Gregory, Mark, Houlton, Jeffrey, Clayburgh, Daniel, Swiecicki, Paul, Huszar, Dennis, Berger, Allison, Klinghoffer, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502463/
https://www.ncbi.nlm.nih.gov/pubmed/37389981
http://dx.doi.org/10.1158/1078-0432.CCR-23-0827

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