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Mesenchymal Stem Cell Therapy in Acute Liver Failure

Acute liver failure (ALF) is a severe liver disease syndrome with rapid deterioration and high mortality. Liver transplantation is the most effective treatment, but the lack of donor livers and the high cost of transplantation limit its broad application. In recent years, there has been no breakthro...

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Detalles Bibliográficos
Autores principales: Wang, Yong-Hong, Chen, En-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502502/
https://www.ncbi.nlm.nih.gov/pubmed/36843422
http://dx.doi.org/10.5009/gnl220417
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author Wang, Yong-Hong
Chen, En-Qiang
author_facet Wang, Yong-Hong
Chen, En-Qiang
author_sort Wang, Yong-Hong
collection PubMed
description Acute liver failure (ALF) is a severe liver disease syndrome with rapid deterioration and high mortality. Liver transplantation is the most effective treatment, but the lack of donor livers and the high cost of transplantation limit its broad application. In recent years, there has been no breakthrough in the treatment of ALF, and the application of stem cells in the treatment of ALF is a crucial research field. Mesenchymal stem cells (MSCs) are widely used in disease treatment research due to their abundant sources, low immunogenicity, and no ethical restrictions. Although MSCs are effective for treating ALF, the application of MSCs to ALF needs to be further studied and optimized. In this review, we discuss the potential mechanisms of MSCs therapy for ALF, summarize some methods to enhance the efficacy of MSCs, and explore optimal approaches for MSC transplantation.
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spelling pubmed-105025022023-09-16 Mesenchymal Stem Cell Therapy in Acute Liver Failure Wang, Yong-Hong Chen, En-Qiang Gut Liver Review Article Acute liver failure (ALF) is a severe liver disease syndrome with rapid deterioration and high mortality. Liver transplantation is the most effective treatment, but the lack of donor livers and the high cost of transplantation limit its broad application. In recent years, there has been no breakthrough in the treatment of ALF, and the application of stem cells in the treatment of ALF is a crucial research field. Mesenchymal stem cells (MSCs) are widely used in disease treatment research due to their abundant sources, low immunogenicity, and no ethical restrictions. Although MSCs are effective for treating ALF, the application of MSCs to ALF needs to be further studied and optimized. In this review, we discuss the potential mechanisms of MSCs therapy for ALF, summarize some methods to enhance the efficacy of MSCs, and explore optimal approaches for MSC transplantation. Editorial Office of Gut and Liver 2023-09-15 2023-02-27 /pmc/articles/PMC10502502/ /pubmed/36843422 http://dx.doi.org/10.5009/gnl220417 Text en Copyright © Gut and Liver. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Yong-Hong
Chen, En-Qiang
Mesenchymal Stem Cell Therapy in Acute Liver Failure
title Mesenchymal Stem Cell Therapy in Acute Liver Failure
title_full Mesenchymal Stem Cell Therapy in Acute Liver Failure
title_fullStr Mesenchymal Stem Cell Therapy in Acute Liver Failure
title_full_unstemmed Mesenchymal Stem Cell Therapy in Acute Liver Failure
title_short Mesenchymal Stem Cell Therapy in Acute Liver Failure
title_sort mesenchymal stem cell therapy in acute liver failure
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502502/
https://www.ncbi.nlm.nih.gov/pubmed/36843422
http://dx.doi.org/10.5009/gnl220417
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