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Red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in China

BACKGROUND: Red cell distribution width (RDW) can signal poor prognosis in inflammatory medical conditions. The purpose of the study was to investigate the relationship between preoperative RDW and colorectal cancer (CRC) in a large cohort of patients. METHODS: A total of 6,224 CRC patients who unde...

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Autores principales: Zhao, Weiwei, Shen, Xuefang, Hua, Qing, Yang, Liu, Zhou, Ru, Zhou, Changming, Xu, Pingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502564/
https://www.ncbi.nlm.nih.gov/pubmed/37720452
http://dx.doi.org/10.21037/jgo-23-54
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author Zhao, Weiwei
Shen, Xuefang
Hua, Qing
Yang, Liu
Zhou, Ru
Zhou, Changming
Xu, Pingbo
author_facet Zhao, Weiwei
Shen, Xuefang
Hua, Qing
Yang, Liu
Zhou, Ru
Zhou, Changming
Xu, Pingbo
author_sort Zhao, Weiwei
collection PubMed
description BACKGROUND: Red cell distribution width (RDW) can signal poor prognosis in inflammatory medical conditions. The purpose of the study was to investigate the relationship between preoperative RDW and colorectal cancer (CRC) in a large cohort of patients. METHODS: A total of 6,224 CRC patients who underwent radical resection at the Fudan University Shanghai Cancer Center were evaluated retrospectively. The prognostic significance of RDW for overall survival (OS) and disease-free survival (DFS) was analyzed using Cox proportional hazards models and Kaplan-Meier method. Propensity score matching (PSM) was used based on survival confounding factors. RESULTS: The mean age of the study participants was 59.5±12.0 years and the study cohort was 44% female. The overall median and mean RDW values were 13.3% and 14.0%, respectively. Patients were stratified into three groups based on their RDW value (≤13.3%, 13.4–14.0%, and >14.0%). OS and DFS were shown to significantly deteriorate with increasing RDW category. In the PSM population, OS and DFS were significantly lower in the high RDW group compared with matched controls. However, the differences vanished in the comparisons between the middle RDW group and the control group. CONCLUSIONS: Our findings demonstrate that preoperative RDW may represent a simple and powerful prognostic factor for CRC patients after radical resection. Integrating RDW into clinical practice may better inform the prognosis and optimize therapeutic approaches for patients with CRC.
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spelling pubmed-105025642023-09-16 Red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in China Zhao, Weiwei Shen, Xuefang Hua, Qing Yang, Liu Zhou, Ru Zhou, Changming Xu, Pingbo J Gastrointest Oncol Original Article BACKGROUND: Red cell distribution width (RDW) can signal poor prognosis in inflammatory medical conditions. The purpose of the study was to investigate the relationship between preoperative RDW and colorectal cancer (CRC) in a large cohort of patients. METHODS: A total of 6,224 CRC patients who underwent radical resection at the Fudan University Shanghai Cancer Center were evaluated retrospectively. The prognostic significance of RDW for overall survival (OS) and disease-free survival (DFS) was analyzed using Cox proportional hazards models and Kaplan-Meier method. Propensity score matching (PSM) was used based on survival confounding factors. RESULTS: The mean age of the study participants was 59.5±12.0 years and the study cohort was 44% female. The overall median and mean RDW values were 13.3% and 14.0%, respectively. Patients were stratified into three groups based on their RDW value (≤13.3%, 13.4–14.0%, and >14.0%). OS and DFS were shown to significantly deteriorate with increasing RDW category. In the PSM population, OS and DFS were significantly lower in the high RDW group compared with matched controls. However, the differences vanished in the comparisons between the middle RDW group and the control group. CONCLUSIONS: Our findings demonstrate that preoperative RDW may represent a simple and powerful prognostic factor for CRC patients after radical resection. Integrating RDW into clinical practice may better inform the prognosis and optimize therapeutic approaches for patients with CRC. AME Publishing Company 2023-07-26 2023-08-31 /pmc/articles/PMC10502564/ /pubmed/37720452 http://dx.doi.org/10.21037/jgo-23-54 Text en 2023 Journal of Gastrointestinal Oncology. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Zhao, Weiwei
Shen, Xuefang
Hua, Qing
Yang, Liu
Zhou, Ru
Zhou, Changming
Xu, Pingbo
Red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in China
title Red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in China
title_full Red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in China
title_fullStr Red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in China
title_full_unstemmed Red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in China
title_short Red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in China
title_sort red cell distribution width—a potential prognostic indicator for colorectal cancer patients after radical resection in china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502564/
https://www.ncbi.nlm.nih.gov/pubmed/37720452
http://dx.doi.org/10.21037/jgo-23-54
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