Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p

Breast cancer (BC) has become a threat to women's health. In addition, patients with triple-negative BC (TNBC) have the worst prognosis among all patients with BC. Furthermore, long non-coding RNA ABHD11-AS1 is aberrantly highly expressed in TNBC, suggesting that RNA ABHD11-AS1 may serve as an...

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Autores principales: Dong, Ying, Zhang, Ting, Shao, Shengwen, Li, Xining, Jiang, Peiyu, Guo, Yue, Gu, Donghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502577/
https://www.ncbi.nlm.nih.gov/pubmed/37719680
http://dx.doi.org/10.3892/br.2023.1651
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author Dong, Ying
Zhang, Ting
Shao, Shengwen
Li, Xining
Jiang, Peiyu
Guo, Yue
Gu, Donghua
author_facet Dong, Ying
Zhang, Ting
Shao, Shengwen
Li, Xining
Jiang, Peiyu
Guo, Yue
Gu, Donghua
author_sort Dong, Ying
collection PubMed
description Breast cancer (BC) has become a threat to women's health. In addition, patients with triple-negative BC (TNBC) have the worst prognosis among all patients with BC. Furthermore, long non-coding RNA ABHD11-AS1 is aberrantly highly expressed in TNBC, suggesting that RNA ABHD11-AS1 may serve as an important role in the progression of TNBC. However, the detailed function of ABHD11-AS1 in TNBC remains largely unknown. The levels of ABHD11-AS1 in MDA-MB-231 cells were assessed by reverse transcription-quantitative PCR. To investigate the effect of ABHD11-AS1 on the progression of TNBC, a xenograft animal model was established. Knockdown of ABHD11-AS1 inhibited the epithelial-mesenchymal transition and migration of TNBC cells. In addition, ABHD11-AS1 promoted the viability and migration of TNBC cells by upregulating microRNA (miR)-199a-5p. Furthermore, knockdown of ABHD11-AS1 suppressed TNBC tumor growth in vivo by upregulating miR-199a-5p. In conclusion, knockdown of ABHD11-AS1 suppressed the progression of TNBC via upregulation of miR-199a-5p. The data of the present study may provide novel directions and a theoretical basis for TNBC treatment.
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spelling pubmed-105025772023-09-16 Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p Dong, Ying Zhang, Ting Shao, Shengwen Li, Xining Jiang, Peiyu Guo, Yue Gu, Donghua Biomed Rep Articles Breast cancer (BC) has become a threat to women's health. In addition, patients with triple-negative BC (TNBC) have the worst prognosis among all patients with BC. Furthermore, long non-coding RNA ABHD11-AS1 is aberrantly highly expressed in TNBC, suggesting that RNA ABHD11-AS1 may serve as an important role in the progression of TNBC. However, the detailed function of ABHD11-AS1 in TNBC remains largely unknown. The levels of ABHD11-AS1 in MDA-MB-231 cells were assessed by reverse transcription-quantitative PCR. To investigate the effect of ABHD11-AS1 on the progression of TNBC, a xenograft animal model was established. Knockdown of ABHD11-AS1 inhibited the epithelial-mesenchymal transition and migration of TNBC cells. In addition, ABHD11-AS1 promoted the viability and migration of TNBC cells by upregulating microRNA (miR)-199a-5p. Furthermore, knockdown of ABHD11-AS1 suppressed TNBC tumor growth in vivo by upregulating miR-199a-5p. In conclusion, knockdown of ABHD11-AS1 suppressed the progression of TNBC via upregulation of miR-199a-5p. The data of the present study may provide novel directions and a theoretical basis for TNBC treatment. D.A. Spandidos 2023-08-23 /pmc/articles/PMC10502577/ /pubmed/37719680 http://dx.doi.org/10.3892/br.2023.1651 Text en Copyright: © Dong et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Dong, Ying
Zhang, Ting
Shao, Shengwen
Li, Xining
Jiang, Peiyu
Guo, Yue
Gu, Donghua
Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p
title Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p
title_full Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p
title_fullStr Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p
title_full_unstemmed Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p
title_short Knockdown of ABHD11‑AS1 prevents the procession of TNBC by upregulating miR‑199a‑5p
title_sort knockdown of abhd11‑as1 prevents the procession of tnbc by upregulating mir‑199a‑5p
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502577/
https://www.ncbi.nlm.nih.gov/pubmed/37719680
http://dx.doi.org/10.3892/br.2023.1651
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