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Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)

Gastrointestinal Cancers Ferroptosis, necroptosis, and pyroptosis all contributed to the development of gastrointestinal cancers. The inactivation of GPX4 or inhibition of System Xc‐ can result in ferroptosis due to the accumulation of lipid peroxides. The binding of cell surface death receptors and...

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Detalles Bibliográficos
Autores principales: Zhu, Xudong, Li, Shenglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502648/
http://dx.doi.org/10.1002/advs.202370174
Descripción
Sumario:Gastrointestinal Cancers Ferroptosis, necroptosis, and pyroptosis all contributed to the development of gastrointestinal cancers. The inactivation of GPX4 or inhibition of System Xc‐ can result in ferroptosis due to the accumulation of lipid peroxides. The binding of cell surface death receptors and ZBP1 could trigger the necrosis. Interaction of PAMP and DAMP with pattern recognition receptors on the cell surface triggers the classical pyroptosis pathway. More details can be found in article number 2300824 by Xudong Zhu and Shenglong Li. [Image: see text]