Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)

Gastrointestinal Cancers Ferroptosis, necroptosis, and pyroptosis all contributed to the development of gastrointestinal cancers. The inactivation of GPX4 or inhibition of System Xc‐ can result in ferroptosis due to the accumulation of lipid peroxides. The binding of cell surface death receptors and...

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Autores principales: Zhu, Xudong, Li, Shenglong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Cover Picture
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502648/
http://dx.doi.org/10.1002/advs.202370174
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author Zhu, Xudong
Li, Shenglong
author_facet Zhu, Xudong
Li, Shenglong
author_sort Zhu, Xudong
collection PubMed
description Gastrointestinal Cancers Ferroptosis, necroptosis, and pyroptosis all contributed to the development of gastrointestinal cancers. The inactivation of GPX4 or inhibition of System Xc‐ can result in ferroptosis due to the accumulation of lipid peroxides. The binding of cell surface death receptors and ZBP1 could trigger the necrosis. Interaction of PAMP and DAMP with pattern recognition receptors on the cell surface triggers the classical pyroptosis pathway. More details can be found in article number 2300824 by Xudong Zhu and Shenglong Li. [Image: see text]
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spelling pubmed-105026482023-09-16 Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023) Zhu, Xudong Li, Shenglong Adv Sci (Weinh) Cover Picture Gastrointestinal Cancers Ferroptosis, necroptosis, and pyroptosis all contributed to the development of gastrointestinal cancers. The inactivation of GPX4 or inhibition of System Xc‐ can result in ferroptosis due to the accumulation of lipid peroxides. The binding of cell surface death receptors and ZBP1 could trigger the necrosis. Interaction of PAMP and DAMP with pattern recognition receptors on the cell surface triggers the classical pyroptosis pathway. More details can be found in article number 2300824 by Xudong Zhu and Shenglong Li. [Image: see text] John Wiley and Sons Inc. 2023-09-15 /pmc/articles/PMC10502648/ http://dx.doi.org/10.1002/advs.202370174 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Cover Picture
Zhu, Xudong
Li, Shenglong
Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)
title Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)
title_full Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)
title_fullStr Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)
title_full_unstemmed Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)
title_short Ferroptosis, Necroptosis, and Pyroptosis in Gastrointestinal Cancers: The Chief Culprits of Tumor Progression and Drug Resistance (Adv. Sci. 26/2023)
title_sort ferroptosis, necroptosis, and pyroptosis in gastrointestinal cancers: the chief culprits of tumor progression and drug resistance (adv. sci. 26/2023)
topic Cover Picture
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502648/
http://dx.doi.org/10.1002/advs.202370174
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