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Modification of the existing maximum residue levels for mefentrifluconazole in various commodities

In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF Agro B.V. Arnhem (NL) Freienbach Branch submitted a request to the competent national authority in Austria to modify the existing maximum residue levels (MRLs) for the active substance mefentrifluconazole in various crop...

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Autores principales: Bellisai, Giulia, Bernasconi, Giovanni, Carrasco Cabrera, Luis, Castellan, Irene, del Aguila, Monica, Ferreira, Lucien, Santonja, German Giner, Greco, Luna, Jarrah, Samira, Leuschner, Renata, Perez, Javier Martinez, Miron, Ileana, Nave, Stefanie, Pedersen, Ragnor, Reich, Hermine, Ruocco, Silvia, Santos, Miguel, Scarlato, Alessia Pia, Theobald, Anne, Tiramani, Manuela, Verani, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502649/
https://www.ncbi.nlm.nih.gov/pubmed/37719918
http://dx.doi.org/10.2903/j.efsa.2023.8237
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author Bellisai, Giulia
Bernasconi, Giovanni
Carrasco Cabrera, Luis
Castellan, Irene
del Aguila, Monica
Ferreira, Lucien
Santonja, German Giner
Greco, Luna
Jarrah, Samira
Leuschner, Renata
Perez, Javier Martinez
Miron, Ileana
Nave, Stefanie
Pedersen, Ragnor
Reich, Hermine
Ruocco, Silvia
Santos, Miguel
Scarlato, Alessia Pia
Theobald, Anne
Tiramani, Manuela
Verani, Alessia
author_facet Bellisai, Giulia
Bernasconi, Giovanni
Carrasco Cabrera, Luis
Castellan, Irene
del Aguila, Monica
Ferreira, Lucien
Santonja, German Giner
Greco, Luna
Jarrah, Samira
Leuschner, Renata
Perez, Javier Martinez
Miron, Ileana
Nave, Stefanie
Pedersen, Ragnor
Reich, Hermine
Ruocco, Silvia
Santos, Miguel
Scarlato, Alessia Pia
Theobald, Anne
Tiramani, Manuela
Verani, Alessia
collection PubMed
description In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF Agro B.V. Arnhem (NL) Freienbach Branch submitted a request to the competent national authority in Austria to modify the existing maximum residue levels (MRLs) for the active substance mefentrifluconazole in various crops and swine liver and other swine products. The data submitted in support of the request were found to be sufficient to derive MRL proposals. Adequate analytical methods for enforcement are available to control the residues of mefentrifluconazole in the plant commodities under consideration and in animal matrices at the validated limit of quantification (LOQ) of 0.01 mg/kg. New data relevant to the data gaps on storage stability and feeding studies of triazole derivative metabolites (TDMs), that were identified during the peer review of confirmatory data of the TDMs, were submitted in support of the present MRL application. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of mefentrifluconazole according to the reported agricultural practices is unlikely to present a risk to consumer health. EFSA noted a narrow safety margin with regard to acute exposure to mefentrifluconazole residues from the intake of spinaches if residues occur at the level of the proposed MRL. EFSA also performed an indicative risk assessment for the TDMs based on uses of mefentrifluconazole only. The estimated exposure for TDMs did not exceed the toxicological reference values.
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spelling pubmed-105026492023-09-16 Modification of the existing maximum residue levels for mefentrifluconazole in various commodities Bellisai, Giulia Bernasconi, Giovanni Carrasco Cabrera, Luis Castellan, Irene del Aguila, Monica Ferreira, Lucien Santonja, German Giner Greco, Luna Jarrah, Samira Leuschner, Renata Perez, Javier Martinez Miron, Ileana Nave, Stefanie Pedersen, Ragnor Reich, Hermine Ruocco, Silvia Santos, Miguel Scarlato, Alessia Pia Theobald, Anne Tiramani, Manuela Verani, Alessia EFSA J Reasoned Opinion In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF Agro B.V. Arnhem (NL) Freienbach Branch submitted a request to the competent national authority in Austria to modify the existing maximum residue levels (MRLs) for the active substance mefentrifluconazole in various crops and swine liver and other swine products. The data submitted in support of the request were found to be sufficient to derive MRL proposals. Adequate analytical methods for enforcement are available to control the residues of mefentrifluconazole in the plant commodities under consideration and in animal matrices at the validated limit of quantification (LOQ) of 0.01 mg/kg. New data relevant to the data gaps on storage stability and feeding studies of triazole derivative metabolites (TDMs), that were identified during the peer review of confirmatory data of the TDMs, were submitted in support of the present MRL application. Based on the risk assessment results, EFSA concluded that the short‐term and long‐term intake of residues resulting from the use of mefentrifluconazole according to the reported agricultural practices is unlikely to present a risk to consumer health. EFSA noted a narrow safety margin with regard to acute exposure to mefentrifluconazole residues from the intake of spinaches if residues occur at the level of the proposed MRL. EFSA also performed an indicative risk assessment for the TDMs based on uses of mefentrifluconazole only. The estimated exposure for TDMs did not exceed the toxicological reference values. John Wiley and Sons Inc. 2023-09-15 /pmc/articles/PMC10502649/ /pubmed/37719918 http://dx.doi.org/10.2903/j.efsa.2023.8237 Text en © 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Reasoned Opinion
Bellisai, Giulia
Bernasconi, Giovanni
Carrasco Cabrera, Luis
Castellan, Irene
del Aguila, Monica
Ferreira, Lucien
Santonja, German Giner
Greco, Luna
Jarrah, Samira
Leuschner, Renata
Perez, Javier Martinez
Miron, Ileana
Nave, Stefanie
Pedersen, Ragnor
Reich, Hermine
Ruocco, Silvia
Santos, Miguel
Scarlato, Alessia Pia
Theobald, Anne
Tiramani, Manuela
Verani, Alessia
Modification of the existing maximum residue levels for mefentrifluconazole in various commodities
title Modification of the existing maximum residue levels for mefentrifluconazole in various commodities
title_full Modification of the existing maximum residue levels for mefentrifluconazole in various commodities
title_fullStr Modification of the existing maximum residue levels for mefentrifluconazole in various commodities
title_full_unstemmed Modification of the existing maximum residue levels for mefentrifluconazole in various commodities
title_short Modification of the existing maximum residue levels for mefentrifluconazole in various commodities
title_sort modification of the existing maximum residue levels for mefentrifluconazole in various commodities
topic Reasoned Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502649/
https://www.ncbi.nlm.nih.gov/pubmed/37719918
http://dx.doi.org/10.2903/j.efsa.2023.8237
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