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HLA in isolated REM sleep behavior disorder and Lewy body dementia
Synucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1*11:0...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502660/ https://www.ncbi.nlm.nih.gov/pubmed/37401389 http://dx.doi.org/10.1002/acn3.51841 |
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| author | Yu, Eric Krohn, Lynne Ruskey, Jennifer A. Asayesh, Farnaz Spiegelman, Dan Shah, Zalak Chia, Ruth Arnulf, Isabelle Hu, Michele T. M. Montplaisir, Jacques Y. Gagnon, Jean‐François Desautels, Alex Dauvilliers, Yves Gigli, Gian Luigi Valente, Mariarosaria Janes, Francesco Bernardini, Andrea Högl, Birgit Stefani, Ambra Ibrahim, Abubaker Heidbreder, Anna Sonka, Karel Dusek, Petr Kemlink, David Oertel, Wolfgang Janzen, Annette Plazzi, Giuseppe Antelmi, Elena Figorilli, Michela Puligheddu, Monica Mollenhauer, Brit Trenkwalder, Claudia Sixel‐Döring, Friederike Cochen De Cock, Valérie Ferini‐Strambi, Luigi Dijkstra, Femke Viaene, Mineke Abril, Beatriz Boeve, Bradley F. Rouleau, Guy A. Postuma, Ronald B. Scholz, Sonja W. Gan‐Or, Ziv |
| author_facet | Yu, Eric Krohn, Lynne Ruskey, Jennifer A. Asayesh, Farnaz Spiegelman, Dan Shah, Zalak Chia, Ruth Arnulf, Isabelle Hu, Michele T. M. Montplaisir, Jacques Y. Gagnon, Jean‐François Desautels, Alex Dauvilliers, Yves Gigli, Gian Luigi Valente, Mariarosaria Janes, Francesco Bernardini, Andrea Högl, Birgit Stefani, Ambra Ibrahim, Abubaker Heidbreder, Anna Sonka, Karel Dusek, Petr Kemlink, David Oertel, Wolfgang Janzen, Annette Plazzi, Giuseppe Antelmi, Elena Figorilli, Michela Puligheddu, Monica Mollenhauer, Brit Trenkwalder, Claudia Sixel‐Döring, Friederike Cochen De Cock, Valérie Ferini‐Strambi, Luigi Dijkstra, Femke Viaene, Mineke Abril, Beatriz Boeve, Bradley F. Rouleau, Guy A. Postuma, Ronald B. Scholz, Sonja W. Gan‐Or, Ziv |
| author_sort | Yu, Eric |
| collection | PubMed |
| description | Synucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27–1.93, p = 2.70e‐05). We also discovered associations between iRBD and HLA‐DRB1 70D (OR = 1.26, 95%CI = 1.12–1.41, p = 8.76e‐05), 70Q (OR = 0.81, 95%CI = 0.72–0.91, p = 3.65e‐04) and 71R (OR = 1.21, 95%CI = 1.08–1.35, p = 1.35e‐03). Position 71 (p (omnibus) = 0.00102) and 70 (p (omnibus) = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies. |
| format | Online Article Text |
| id | pubmed-10502660 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105026602023-09-16 HLA in isolated REM sleep behavior disorder and Lewy body dementia Yu, Eric Krohn, Lynne Ruskey, Jennifer A. Asayesh, Farnaz Spiegelman, Dan Shah, Zalak Chia, Ruth Arnulf, Isabelle Hu, Michele T. M. Montplaisir, Jacques Y. Gagnon, Jean‐François Desautels, Alex Dauvilliers, Yves Gigli, Gian Luigi Valente, Mariarosaria Janes, Francesco Bernardini, Andrea Högl, Birgit Stefani, Ambra Ibrahim, Abubaker Heidbreder, Anna Sonka, Karel Dusek, Petr Kemlink, David Oertel, Wolfgang Janzen, Annette Plazzi, Giuseppe Antelmi, Elena Figorilli, Michela Puligheddu, Monica Mollenhauer, Brit Trenkwalder, Claudia Sixel‐Döring, Friederike Cochen De Cock, Valérie Ferini‐Strambi, Luigi Dijkstra, Femke Viaene, Mineke Abril, Beatriz Boeve, Bradley F. Rouleau, Guy A. Postuma, Ronald B. Scholz, Sonja W. Gan‐Or, Ziv Ann Clin Transl Neurol Brief Communications Synucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27–1.93, p = 2.70e‐05). We also discovered associations between iRBD and HLA‐DRB1 70D (OR = 1.26, 95%CI = 1.12–1.41, p = 8.76e‐05), 70Q (OR = 0.81, 95%CI = 0.72–0.91, p = 3.65e‐04) and 71R (OR = 1.21, 95%CI = 1.08–1.35, p = 1.35e‐03). Position 71 (p (omnibus) = 0.00102) and 70 (p (omnibus) = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies. John Wiley and Sons Inc. 2023-07-04 /pmc/articles/PMC10502660/ /pubmed/37401389 http://dx.doi.org/10.1002/acn3.51841 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Brief Communications Yu, Eric Krohn, Lynne Ruskey, Jennifer A. Asayesh, Farnaz Spiegelman, Dan Shah, Zalak Chia, Ruth Arnulf, Isabelle Hu, Michele T. M. Montplaisir, Jacques Y. Gagnon, Jean‐François Desautels, Alex Dauvilliers, Yves Gigli, Gian Luigi Valente, Mariarosaria Janes, Francesco Bernardini, Andrea Högl, Birgit Stefani, Ambra Ibrahim, Abubaker Heidbreder, Anna Sonka, Karel Dusek, Petr Kemlink, David Oertel, Wolfgang Janzen, Annette Plazzi, Giuseppe Antelmi, Elena Figorilli, Michela Puligheddu, Monica Mollenhauer, Brit Trenkwalder, Claudia Sixel‐Döring, Friederike Cochen De Cock, Valérie Ferini‐Strambi, Luigi Dijkstra, Femke Viaene, Mineke Abril, Beatriz Boeve, Bradley F. Rouleau, Guy A. Postuma, Ronald B. Scholz, Sonja W. Gan‐Or, Ziv HLA in isolated REM sleep behavior disorder and Lewy body dementia |
| title |
HLA
in isolated REM sleep behavior disorder and Lewy body dementia |
| title_full |
HLA
in isolated REM sleep behavior disorder and Lewy body dementia |
| title_fullStr |
HLA
in isolated REM sleep behavior disorder and Lewy body dementia |
| title_full_unstemmed |
HLA
in isolated REM sleep behavior disorder and Lewy body dementia |
| title_short |
HLA
in isolated REM sleep behavior disorder and Lewy body dementia |
| title_sort | hla
in isolated rem sleep behavior disorder and lewy body dementia |
| topic | Brief Communications |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502660/ https://www.ncbi.nlm.nih.gov/pubmed/37401389 http://dx.doi.org/10.1002/acn3.51841 |
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