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Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023)
Coronavirus Disease Benzo[a]pyrene is a major active ingredient of cigarette smoke that induces the expression of a transcription factor, NR4A2, and promotes the binding of NR4A2 to promoters of ACE2 and TMPRSS2. Thus, benzo[a]pyrene promotes the infection of SARS‐CoV‐2 through up‐regulating two rec...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502676/ http://dx.doi.org/10.1002/advs.202370178 |
| _version_ | 1785106372613898240 |
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| author | Liu, Wenbin Zhao, Yue Fan, Junyan Shen, Jiaying Tang, Hailin Tang, Wanda Wu, Di Huang, Weijin Ding, Yibo Qiao, Peng Lin, Jiansheng Li, Zishuai Li, Qianqian Cui, Qianqian Liu, Yan Chen, Yifan Pu, Rui Han, Xue Yin, Jianhua Tan, Xiaojie Cao, Guangwen |
| author_facet | Liu, Wenbin Zhao, Yue Fan, Junyan Shen, Jiaying Tang, Hailin Tang, Wanda Wu, Di Huang, Weijin Ding, Yibo Qiao, Peng Lin, Jiansheng Li, Zishuai Li, Qianqian Cui, Qianqian Liu, Yan Chen, Yifan Pu, Rui Han, Xue Yin, Jianhua Tan, Xiaojie Cao, Guangwen |
| author_sort | Liu, Wenbin |
| collection | PubMed |
| description | Coronavirus Disease Benzo[a]pyrene is a major active ingredient of cigarette smoke that induces the expression of a transcription factor, NR4A2, and promotes the binding of NR4A2 to promoters of ACE2 and TMPRSS2. Thus, benzo[a]pyrene promotes the infection of SARS‐CoV‐2 through up‐regulating two receptors of SARS‐CoV‐2. This study elucidates the mechanisms underlying the detrimental effects of cigarette smoking on SARS‐CoV‐2 infection and provides prophylactic options for COVID‐19. More details can be found in article number 2300834 by Guangwen Cao and co‐workers. [Image: see text] |
| format | Online Article Text |
| id | pubmed-10502676 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105026762023-09-16 Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023) Liu, Wenbin Zhao, Yue Fan, Junyan Shen, Jiaying Tang, Hailin Tang, Wanda Wu, Di Huang, Weijin Ding, Yibo Qiao, Peng Lin, Jiansheng Li, Zishuai Li, Qianqian Cui, Qianqian Liu, Yan Chen, Yifan Pu, Rui Han, Xue Yin, Jianhua Tan, Xiaojie Cao, Guangwen Adv Sci (Weinh) Inside Back Cover Coronavirus Disease Benzo[a]pyrene is a major active ingredient of cigarette smoke that induces the expression of a transcription factor, NR4A2, and promotes the binding of NR4A2 to promoters of ACE2 and TMPRSS2. Thus, benzo[a]pyrene promotes the infection of SARS‐CoV‐2 through up‐regulating two receptors of SARS‐CoV‐2. This study elucidates the mechanisms underlying the detrimental effects of cigarette smoking on SARS‐CoV‐2 infection and provides prophylactic options for COVID‐19. More details can be found in article number 2300834 by Guangwen Cao and co‐workers. [Image: see text] John Wiley and Sons Inc. 2023-09-15 /pmc/articles/PMC10502676/ http://dx.doi.org/10.1002/advs.202370178 Text en © 2023 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| spellingShingle | Inside Back Cover Liu, Wenbin Zhao, Yue Fan, Junyan Shen, Jiaying Tang, Hailin Tang, Wanda Wu, Di Huang, Weijin Ding, Yibo Qiao, Peng Lin, Jiansheng Li, Zishuai Li, Qianqian Cui, Qianqian Liu, Yan Chen, Yifan Pu, Rui Han, Xue Yin, Jianhua Tan, Xiaojie Cao, Guangwen Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023) |
| title | Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023) |
| title_full | Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023) |
| title_fullStr | Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023) |
| title_full_unstemmed | Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023) |
| title_short | Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023) |
| title_sort | smoke and spike: benzo[a]pyrene enhances sars‐cov‐2 infection by boosting nr4a2‐induced ace2 and tmprss2 expression (adv. sci. 26/2023) |
| topic | Inside Back Cover |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502676/ http://dx.doi.org/10.1002/advs.202370178 |
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