Smoke and Spike: Benzo[a]pyrene Enhances SARS‐CoV‐2 Infection by Boosting NR4A2‐Induced ACE2 and TMPRSS2 Expression (Adv. Sci. 26/2023)

Coronavirus Disease Benzo[a]pyrene is a major active ingredient of cigarette smoke that induces the expression of a transcription factor, NR4A2, and promotes the binding of NR4A2 to promoters of ACE2 and TMPRSS2. Thus, benzo[a]pyrene promotes the infection of SARS‐CoV‐2 through up‐regulating two rec...

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Detalles Bibliográficos
Autores principales: Liu, Wenbin, Zhao, Yue, Fan, Junyan, Shen, Jiaying, Tang, Hailin, Tang, Wanda, Wu, Di, Huang, Weijin, Ding, Yibo, Qiao, Peng, Lin, Jiansheng, Li, Zishuai, Li, Qianqian, Cui, Qianqian, Liu, Yan, Chen, Yifan, Pu, Rui, Han, Xue, Yin, Jianhua, Tan, Xiaojie, Cao, Guangwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502676/
http://dx.doi.org/10.1002/advs.202370178

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