Cargando…

Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure

BACKGROUND: Previous studies have found associations of red blood cell (RBC) traits (hemoglobin and RBC count) with blood pressure; whether these associations are causal is unknown. METHODS: We performed cross-sectional analyses in the Lifelines Cohort Study (n = 167,785). Additionally, we performed...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Zhen, Chen, Zekai, de Borst, Martin H, Zhang, Qingying, Snieder, Harold, Thio, Chris H L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502771/
https://www.ncbi.nlm.nih.gov/pubmed/37432331
http://dx.doi.org/10.1093/ajh/hpad061
_version_ 1785106389392162816
author He, Zhen
Chen, Zekai
de Borst, Martin H
Zhang, Qingying
Snieder, Harold
Thio, Chris H L
author_facet He, Zhen
Chen, Zekai
de Borst, Martin H
Zhang, Qingying
Snieder, Harold
Thio, Chris H L
author_sort He, Zhen
collection PubMed
description BACKGROUND: Previous studies have found associations of red blood cell (RBC) traits (hemoglobin and RBC count) with blood pressure; whether these associations are causal is unknown. METHODS: We performed cross-sectional analyses in the Lifelines Cohort Study (n = 167,785). Additionally, we performed bidirectional 2 sample Mendelian randomization (MR) analyses to explore the causal effect of the 2 traits on systolic (SBP) and diastolic blood pressure (DBP), using genetic instrumental variables regarding hemoglobin and RBC identified in UK Biobank (n = 350,475) and International Consortium of Blood Pressure studies for SBP and DBP (n = 757,601). RESULTS: In cross-sectional analyses, we observed positive associations with hypertension and blood pressure for both hemoglobin (odds ratio [OR] = 1.18, 95% confidence interval [CI]: 1.16–1.20 for hypertension; B = 0.11, 95% CI: 0.11–0.12 for SBP; B = 0.11, 95% CI: 0.10–0.11 for DBP, all per SD) and RBC (OR = 1.14, 95% CI: 1.12–1.16 for hypertension; B = 0.11, 95% CI: 0.10–0.12 for SBP; B = 0.08, 95% CI: 0.08–0.09 for DBP, all per SD). MR analyses suggested that higher hemoglobin and RBC cause higher DBP (inverse-variance weighted B = 0.11, 95% CI: 0.07–0.16 for hemoglobin; B = 0.07, 95% CI: 0.04–0.10 for RBC, all per SD). Reverse MR analyses (all per SD) suggested causal effects of DBP on both hemoglobin (B = 0.06, 95% CI: 0.03–0.09) and RBC (B = 0.08, 95% CI: 0.04–0.11). No significant effects on SBP were found. CONCLUSIONS: Our results suggest bidirectional causal relationships of hemoglobin and RBC with DBP, but not with SBP.
format Online
Article
Text
id pubmed-10502771
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-105027712023-09-16 Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure He, Zhen Chen, Zekai de Borst, Martin H Zhang, Qingying Snieder, Harold Thio, Chris H L Am J Hypertens Original Contributions BACKGROUND: Previous studies have found associations of red blood cell (RBC) traits (hemoglobin and RBC count) with blood pressure; whether these associations are causal is unknown. METHODS: We performed cross-sectional analyses in the Lifelines Cohort Study (n = 167,785). Additionally, we performed bidirectional 2 sample Mendelian randomization (MR) analyses to explore the causal effect of the 2 traits on systolic (SBP) and diastolic blood pressure (DBP), using genetic instrumental variables regarding hemoglobin and RBC identified in UK Biobank (n = 350,475) and International Consortium of Blood Pressure studies for SBP and DBP (n = 757,601). RESULTS: In cross-sectional analyses, we observed positive associations with hypertension and blood pressure for both hemoglobin (odds ratio [OR] = 1.18, 95% confidence interval [CI]: 1.16–1.20 for hypertension; B = 0.11, 95% CI: 0.11–0.12 for SBP; B = 0.11, 95% CI: 0.10–0.11 for DBP, all per SD) and RBC (OR = 1.14, 95% CI: 1.12–1.16 for hypertension; B = 0.11, 95% CI: 0.10–0.12 for SBP; B = 0.08, 95% CI: 0.08–0.09 for DBP, all per SD). MR analyses suggested that higher hemoglobin and RBC cause higher DBP (inverse-variance weighted B = 0.11, 95% CI: 0.07–0.16 for hemoglobin; B = 0.07, 95% CI: 0.04–0.10 for RBC, all per SD). Reverse MR analyses (all per SD) suggested causal effects of DBP on both hemoglobin (B = 0.06, 95% CI: 0.03–0.09) and RBC (B = 0.08, 95% CI: 0.04–0.11). No significant effects on SBP were found. CONCLUSIONS: Our results suggest bidirectional causal relationships of hemoglobin and RBC with DBP, but not with SBP. Oxford University Press 2023-07-11 /pmc/articles/PMC10502771/ /pubmed/37432331 http://dx.doi.org/10.1093/ajh/hpad061 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Contributions
He, Zhen
Chen, Zekai
de Borst, Martin H
Zhang, Qingying
Snieder, Harold
Thio, Chris H L
Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure
title Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure
title_full Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure
title_fullStr Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure
title_full_unstemmed Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure
title_short Observational and Genetic Evidence for Bidirectional Effects Between Red Blood Cell Traits and Diastolic Blood Pressure
title_sort observational and genetic evidence for bidirectional effects between red blood cell traits and diastolic blood pressure
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502771/
https://www.ncbi.nlm.nih.gov/pubmed/37432331
http://dx.doi.org/10.1093/ajh/hpad061
work_keys_str_mv AT hezhen observationalandgeneticevidenceforbidirectionaleffectsbetweenredbloodcelltraitsanddiastolicbloodpressure
AT chenzekai observationalandgeneticevidenceforbidirectionaleffectsbetweenredbloodcelltraitsanddiastolicbloodpressure
AT deborstmartinh observationalandgeneticevidenceforbidirectionaleffectsbetweenredbloodcelltraitsanddiastolicbloodpressure
AT zhangqingying observationalandgeneticevidenceforbidirectionaleffectsbetweenredbloodcelltraitsanddiastolicbloodpressure
AT observationalandgeneticevidenceforbidirectionaleffectsbetweenredbloodcelltraitsanddiastolicbloodpressure
AT sniederharold observationalandgeneticevidenceforbidirectionaleffectsbetweenredbloodcelltraitsanddiastolicbloodpressure
AT thiochrishl observationalandgeneticevidenceforbidirectionaleffectsbetweenredbloodcelltraitsanddiastolicbloodpressure