Cargando…
Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy
Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS(2) NF) as piezo‐sonosensitizers and introduced sulfur v...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502820/ https://www.ncbi.nlm.nih.gov/pubmed/37395638 http://dx.doi.org/10.1002/advs.202301152 |
_version_ | 1785106396654600192 |
---|---|
author | Wu, Qingyuan Zhang, Jie Pan, Xueting Huang, Zhijun Zhang, Haoyuan Guo, Juan Xue, Yun Shi, Rui Liu, Huiyu |
author_facet | Wu, Qingyuan Zhang, Jie Pan, Xueting Huang, Zhijun Zhang, Haoyuan Guo, Juan Xue, Yun Shi, Rui Liu, Huiyu |
author_sort | Wu, Qingyuan |
collection | PubMed |
description | Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS(2) NF) as piezo‐sonosensitizers and introduced sulfur vacancies on the MoS(2) NF (Sv‐MoS(2) NF) to improve their piezoelectric property for cancer therapy are designed. Under ultrasonic mechanical stress, the Sv‐MoS(2) NF resulted in piezoelectric polarization and band tilting, which enhanced the charge carrier separation and migration. This resulted in an improved catalytic reaction for reactive oxygen species (ROS) production, ultimately enhancing the SDT performance. Thanks to the high efficiency of ROS generation, the Sv‐MoS(2) NF have demonstrated a good anticancer effect in vitro and in vivo. Following a systematic evaluation, Sv‐MoS(2) NF also demonstrated good biocompatibility. This novel piezo‐sonosensitizer and vacancy engineering strategy provides a promising new approach for achieving efficient SDT. |
format | Online Article Text |
id | pubmed-10502820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105028202023-09-16 Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy Wu, Qingyuan Zhang, Jie Pan, Xueting Huang, Zhijun Zhang, Haoyuan Guo, Juan Xue, Yun Shi, Rui Liu, Huiyu Adv Sci (Weinh) Research Articles Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS(2) NF) as piezo‐sonosensitizers and introduced sulfur vacancies on the MoS(2) NF (Sv‐MoS(2) NF) to improve their piezoelectric property for cancer therapy are designed. Under ultrasonic mechanical stress, the Sv‐MoS(2) NF resulted in piezoelectric polarization and band tilting, which enhanced the charge carrier separation and migration. This resulted in an improved catalytic reaction for reactive oxygen species (ROS) production, ultimately enhancing the SDT performance. Thanks to the high efficiency of ROS generation, the Sv‐MoS(2) NF have demonstrated a good anticancer effect in vitro and in vivo. Following a systematic evaluation, Sv‐MoS(2) NF also demonstrated good biocompatibility. This novel piezo‐sonosensitizer and vacancy engineering strategy provides a promising new approach for achieving efficient SDT. John Wiley and Sons Inc. 2023-07-03 /pmc/articles/PMC10502820/ /pubmed/37395638 http://dx.doi.org/10.1002/advs.202301152 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Wu, Qingyuan Zhang, Jie Pan, Xueting Huang, Zhijun Zhang, Haoyuan Guo, Juan Xue, Yun Shi, Rui Liu, Huiyu Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
title | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
title_full | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
title_fullStr | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
title_full_unstemmed | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
title_short | Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy |
title_sort | vacancy augmented piezo‐sonosensitizer for cancer therapy |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502820/ https://www.ncbi.nlm.nih.gov/pubmed/37395638 http://dx.doi.org/10.1002/advs.202301152 |
work_keys_str_mv | AT wuqingyuan vacancyaugmentedpiezosonosensitizerforcancertherapy AT zhangjie vacancyaugmentedpiezosonosensitizerforcancertherapy AT panxueting vacancyaugmentedpiezosonosensitizerforcancertherapy AT huangzhijun vacancyaugmentedpiezosonosensitizerforcancertherapy AT zhanghaoyuan vacancyaugmentedpiezosonosensitizerforcancertherapy AT guojuan vacancyaugmentedpiezosonosensitizerforcancertherapy AT xueyun vacancyaugmentedpiezosonosensitizerforcancertherapy AT shirui vacancyaugmentedpiezosonosensitizerforcancertherapy AT liuhuiyu vacancyaugmentedpiezosonosensitizerforcancertherapy |