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Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy

Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS(2) NF) as piezo‐sonosensitizers and introduced sulfur v...

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Autores principales: Wu, Qingyuan, Zhang, Jie, Pan, Xueting, Huang, Zhijun, Zhang, Haoyuan, Guo, Juan, Xue, Yun, Shi, Rui, Liu, Huiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502820/
https://www.ncbi.nlm.nih.gov/pubmed/37395638
http://dx.doi.org/10.1002/advs.202301152
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author Wu, Qingyuan
Zhang, Jie
Pan, Xueting
Huang, Zhijun
Zhang, Haoyuan
Guo, Juan
Xue, Yun
Shi, Rui
Liu, Huiyu
author_facet Wu, Qingyuan
Zhang, Jie
Pan, Xueting
Huang, Zhijun
Zhang, Haoyuan
Guo, Juan
Xue, Yun
Shi, Rui
Liu, Huiyu
author_sort Wu, Qingyuan
collection PubMed
description Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS(2) NF) as piezo‐sonosensitizers and introduced sulfur vacancies on the MoS(2) NF (Sv‐MoS(2) NF) to improve their piezoelectric property for cancer therapy are designed. Under ultrasonic mechanical stress, the Sv‐MoS(2) NF resulted in piezoelectric polarization and band tilting, which enhanced the charge carrier separation and migration. This resulted in an improved catalytic reaction for reactive oxygen species (ROS) production, ultimately enhancing the SDT performance. Thanks to the high efficiency of ROS generation, the Sv‐MoS(2) NF have demonstrated a good anticancer effect in vitro and in vivo. Following a systematic evaluation, Sv‐MoS(2) NF also demonstrated good biocompatibility. This novel piezo‐sonosensitizer and vacancy engineering strategy provides a promising new approach for achieving efficient SDT.
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spelling pubmed-105028202023-09-16 Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy Wu, Qingyuan Zhang, Jie Pan, Xueting Huang, Zhijun Zhang, Haoyuan Guo, Juan Xue, Yun Shi, Rui Liu, Huiyu Adv Sci (Weinh) Research Articles Sonodynamic therapy (SDT) has been widely reported as a noninvasive and high‐penetration therapy for cancer; however, the design of an efficient sonosensitizer remains an urgent need. To address this issue, molybdenum disulfide nanoflowers (MoS(2) NF) as piezo‐sonosensitizers and introduced sulfur vacancies on the MoS(2) NF (Sv‐MoS(2) NF) to improve their piezoelectric property for cancer therapy are designed. Under ultrasonic mechanical stress, the Sv‐MoS(2) NF resulted in piezoelectric polarization and band tilting, which enhanced the charge carrier separation and migration. This resulted in an improved catalytic reaction for reactive oxygen species (ROS) production, ultimately enhancing the SDT performance. Thanks to the high efficiency of ROS generation, the Sv‐MoS(2) NF have demonstrated a good anticancer effect in vitro and in vivo. Following a systematic evaluation, Sv‐MoS(2) NF also demonstrated good biocompatibility. This novel piezo‐sonosensitizer and vacancy engineering strategy provides a promising new approach for achieving efficient SDT. John Wiley and Sons Inc. 2023-07-03 /pmc/articles/PMC10502820/ /pubmed/37395638 http://dx.doi.org/10.1002/advs.202301152 Text en © 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Wu, Qingyuan
Zhang, Jie
Pan, Xueting
Huang, Zhijun
Zhang, Haoyuan
Guo, Juan
Xue, Yun
Shi, Rui
Liu, Huiyu
Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy
title Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy
title_full Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy
title_fullStr Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy
title_full_unstemmed Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy
title_short Vacancy Augmented Piezo‐Sonosensitizer for Cancer Therapy
title_sort vacancy augmented piezo‐sonosensitizer for cancer therapy
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502820/
https://www.ncbi.nlm.nih.gov/pubmed/37395638
http://dx.doi.org/10.1002/advs.202301152
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