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Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)

Adipose tissue (AT) is a complicated metabolic organ consisting of a heterogeneous population of cells that exert wide-ranging effects on the regulation of systemic metabolism and in maintaining metabolic homeostasis. Various obesity-related complications are associated with the development of dysfu...

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Autores principales: Yang, Xiaobo, Hao, Jiayue, Luo, Jie, Lu, Xinliang, Kong, Xianghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502927/
https://www.ncbi.nlm.nih.gov/pubmed/37615193
http://dx.doi.org/10.3892/mmr.2023.13076
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author Yang, Xiaobo
Hao, Jiayue
Luo, Jie
Lu, Xinliang
Kong, Xianghui
author_facet Yang, Xiaobo
Hao, Jiayue
Luo, Jie
Lu, Xinliang
Kong, Xianghui
author_sort Yang, Xiaobo
collection PubMed
description Adipose tissue (AT) is a complicated metabolic organ consisting of a heterogeneous population of cells that exert wide-ranging effects on the regulation of systemic metabolism and in maintaining metabolic homeostasis. Various obesity-related complications are associated with the development of dysfunctional AT. As an essential transmitter of intercellular information, extracellular vesicles (EVs) have recently been recognized as crucial in regulating multiple physiological functions. AT-derived extracellular vesicles (ADEVs) have been shown to facilitate cellular communication both inside and between ATs and other peripheral organs. Here, the role of EVs released from ATs in the homeostasis of metabolic and cardiovascular diseases, cancer, and neurological disorders by delivering lipids, proteins, and nucleic acids between different cells is summarized. Furthermore, the differences in the sources of ADEVs, such as adipocytes, AT macrophages, AT-derived stem cells, and AT-derived mesenchymal stem cells, are also discussed. This review may provide valuable information for the potential application of ADEVs in metabolic syndrome, cardiovascular diseases, cancer, and neurological disorders.
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spelling pubmed-105029272023-09-16 Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review) Yang, Xiaobo Hao, Jiayue Luo, Jie Lu, Xinliang Kong, Xianghui Mol Med Rep Review Adipose tissue (AT) is a complicated metabolic organ consisting of a heterogeneous population of cells that exert wide-ranging effects on the regulation of systemic metabolism and in maintaining metabolic homeostasis. Various obesity-related complications are associated with the development of dysfunctional AT. As an essential transmitter of intercellular information, extracellular vesicles (EVs) have recently been recognized as crucial in regulating multiple physiological functions. AT-derived extracellular vesicles (ADEVs) have been shown to facilitate cellular communication both inside and between ATs and other peripheral organs. Here, the role of EVs released from ATs in the homeostasis of metabolic and cardiovascular diseases, cancer, and neurological disorders by delivering lipids, proteins, and nucleic acids between different cells is summarized. Furthermore, the differences in the sources of ADEVs, such as adipocytes, AT macrophages, AT-derived stem cells, and AT-derived mesenchymal stem cells, are also discussed. This review may provide valuable information for the potential application of ADEVs in metabolic syndrome, cardiovascular diseases, cancer, and neurological disorders. D.A. Spandidos 2023-08-23 /pmc/articles/PMC10502927/ /pubmed/37615193 http://dx.doi.org/10.3892/mmr.2023.13076 Text en Copyright: © Yang et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Yang, Xiaobo
Hao, Jiayue
Luo, Jie
Lu, Xinliang
Kong, Xianghui
Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)
title Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)
title_full Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)
title_fullStr Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)
title_full_unstemmed Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)
title_short Adipose tissue‑derived extracellular vesicles: Systemic messengers in health and disease (Review)
title_sort adipose tissue‑derived extracellular vesicles: systemic messengers in health and disease (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502927/
https://www.ncbi.nlm.nih.gov/pubmed/37615193
http://dx.doi.org/10.3892/mmr.2023.13076
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