Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy

This report describes the case of a 70-year-old man with metastatic squamous cell carcinoma (SCC) of the right lower leg. Soon after definitive surgical management of the primary and nodal metastases with curative intent, he relapsed, developing aggressive in-transit metastatic disease and recurrent...

Descripción completa

Detalles Bibliográficos
Autores principales: Furkert, Chris, Martin, Richard, Sharma, Avinash, Rivalland, Gareth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503120/
https://www.ncbi.nlm.nih.gov/pubmed/37715254
http://dx.doi.org/10.1186/s12957-023-03179-3
_version_ 1785106456901582848
author Furkert, Chris
Martin, Richard
Sharma, Avinash
Rivalland, Gareth
author_facet Furkert, Chris
Martin, Richard
Sharma, Avinash
Rivalland, Gareth
author_sort Furkert, Chris
collection PubMed
description This report describes the case of a 70-year-old man with metastatic squamous cell carcinoma (SCC) of the right lower leg. Soon after definitive surgical management of the primary and nodal metastases with curative intent, he relapsed, developing aggressive in-transit metastatic disease and recurrent nodal disease. The patient was treated with systemic immunotherapy alone, which not only prompted the progressive nodal metastases to regress, but also resulted in a complete response of the in-transit disease. This situation is previously undescribed in the medical literature.
format Online
Article
Text
id pubmed-10503120
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-105031202023-09-16 Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy Furkert, Chris Martin, Richard Sharma, Avinash Rivalland, Gareth World J Surg Oncol Case Report This report describes the case of a 70-year-old man with metastatic squamous cell carcinoma (SCC) of the right lower leg. Soon after definitive surgical management of the primary and nodal metastases with curative intent, he relapsed, developing aggressive in-transit metastatic disease and recurrent nodal disease. The patient was treated with systemic immunotherapy alone, which not only prompted the progressive nodal metastases to regress, but also resulted in a complete response of the in-transit disease. This situation is previously undescribed in the medical literature. BioMed Central 2023-09-15 /pmc/articles/PMC10503120/ /pubmed/37715254 http://dx.doi.org/10.1186/s12957-023-03179-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Furkert, Chris
Martin, Richard
Sharma, Avinash
Rivalland, Gareth
Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy
title Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy
title_full Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy
title_fullStr Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy
title_full_unstemmed Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy
title_short Successful management of in-transit cutaneous squamous cell carcinoma with anti-PD-1 immunotherapy
title_sort successful management of in-transit cutaneous squamous cell carcinoma with anti-pd-1 immunotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503120/
https://www.ncbi.nlm.nih.gov/pubmed/37715254
http://dx.doi.org/10.1186/s12957-023-03179-3
work_keys_str_mv AT furkertchris successfulmanagementofintransitcutaneoussquamouscellcarcinomawithantipd1immunotherapy
AT martinrichard successfulmanagementofintransitcutaneoussquamouscellcarcinomawithantipd1immunotherapy
AT sharmaavinash successfulmanagementofintransitcutaneoussquamouscellcarcinomawithantipd1immunotherapy
AT rivallandgareth successfulmanagementofintransitcutaneoussquamouscellcarcinomawithantipd1immunotherapy

Ejemplares similares