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Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation

BACKGROUND: Children with neurodevelopmental disorders have a very wide clinical variability. A common prevalent factor is problems with stool and sleep quality. Currently, there are multiple studies related to their evaluation, but not so much related to a specific intervention. The aim was to eval...

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Autores principales: Báez-Suárez, Aníbal, Padrón-Rodríguez, Iraya, Castellano-Moreno, Elizabeth, González-González, Erica, Quintana-Montesdeoca, María P., Medina-Ramirez, Raquel Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503175/
https://www.ncbi.nlm.nih.gov/pubmed/37715152
http://dx.doi.org/10.1186/s12887-023-04307-4
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author Báez-Suárez, Aníbal
Padrón-Rodríguez, Iraya
Castellano-Moreno, Elizabeth
González-González, Erica
Quintana-Montesdeoca, María P.
Medina-Ramirez, Raquel Irina
author_facet Báez-Suárez, Aníbal
Padrón-Rodríguez, Iraya
Castellano-Moreno, Elizabeth
González-González, Erica
Quintana-Montesdeoca, María P.
Medina-Ramirez, Raquel Irina
author_sort Báez-Suárez, Aníbal
collection PubMed
description BACKGROUND: Children with neurodevelopmental disorders have a very wide clinical variability. A common prevalent factor is problems with stool and sleep quality. Currently, there are multiple studies related to their evaluation, but not so much related to a specific intervention. The aim was to evaluate the effectiveness and safety of the application of non-invasive neuromodulation as a treatment in children with neurodevelopmental disorders to improve constipation and quality of sleep. METHODS: A total of 23 minors aged between 2 and 16 were included in this cross-sectional study. All participants were applied the microcurrent device for 60 min, 3 times per week for a total of 4 weeks. The technique was based on non-invasive neuromodulation using a surface-applied microcurrent electrostimulation device that administers an external, imperceptible, pulsed electrical stimulation. It is applied to the extremities, in a coordinated manner, using gloves and anklets connected with electrodes to a control console. Sleep latency and microarousals were evaluated through a sleep diary. To assess the evolution and type of defecation, the adapted and validated version in Spanish of the Bristol Stool Form Scale was used. RESULTS: No adverse events occurred during the study and no incidences were registered. Clinically relevant improvements were registered in defecation frequency and type as well as in sleep related parameters. An increase in the hours of sleep was registered, from 7,35 (0,83) to 9,09 (1,35), and sleep interruptions decreased from 3,83 (1,95) to 1,17 (1,11), (p < .001). CONCLUSION: Microcurrents can be used as an effective and safe treatment to improve quality of sleep and constipation in children with neurodevelopmental disorders. More studies are needed in order to obtain statistically significant results. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT05265702. FIRST REGISTRATION: 03/03/2022 PROTOCOL: https://clinicaltrials.gov/ct2/show/NCT05265702?term=baez+suarez&draw=2&rank=4
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spelling pubmed-105031752023-09-16 Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation Báez-Suárez, Aníbal Padrón-Rodríguez, Iraya Castellano-Moreno, Elizabeth González-González, Erica Quintana-Montesdeoca, María P. Medina-Ramirez, Raquel Irina BMC Pediatr Research BACKGROUND: Children with neurodevelopmental disorders have a very wide clinical variability. A common prevalent factor is problems with stool and sleep quality. Currently, there are multiple studies related to their evaluation, but not so much related to a specific intervention. The aim was to evaluate the effectiveness and safety of the application of non-invasive neuromodulation as a treatment in children with neurodevelopmental disorders to improve constipation and quality of sleep. METHODS: A total of 23 minors aged between 2 and 16 were included in this cross-sectional study. All participants were applied the microcurrent device for 60 min, 3 times per week for a total of 4 weeks. The technique was based on non-invasive neuromodulation using a surface-applied microcurrent electrostimulation device that administers an external, imperceptible, pulsed electrical stimulation. It is applied to the extremities, in a coordinated manner, using gloves and anklets connected with electrodes to a control console. Sleep latency and microarousals were evaluated through a sleep diary. To assess the evolution and type of defecation, the adapted and validated version in Spanish of the Bristol Stool Form Scale was used. RESULTS: No adverse events occurred during the study and no incidences were registered. Clinically relevant improvements were registered in defecation frequency and type as well as in sleep related parameters. An increase in the hours of sleep was registered, from 7,35 (0,83) to 9,09 (1,35), and sleep interruptions decreased from 3,83 (1,95) to 1,17 (1,11), (p < .001). CONCLUSION: Microcurrents can be used as an effective and safe treatment to improve quality of sleep and constipation in children with neurodevelopmental disorders. More studies are needed in order to obtain statistically significant results. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT05265702. FIRST REGISTRATION: 03/03/2022 PROTOCOL: https://clinicaltrials.gov/ct2/show/NCT05265702?term=baez+suarez&draw=2&rank=4 BioMed Central 2023-09-15 /pmc/articles/PMC10503175/ /pubmed/37715152 http://dx.doi.org/10.1186/s12887-023-04307-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Báez-Suárez, Aníbal
Padrón-Rodríguez, Iraya
Castellano-Moreno, Elizabeth
González-González, Erica
Quintana-Montesdeoca, María P.
Medina-Ramirez, Raquel Irina
Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
title Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
title_full Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
title_fullStr Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
title_full_unstemmed Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
title_short Application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
title_sort application of non-invasive neuromodulation in children with neurodevelopmental disorders to improve their sleep quality and constipation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503175/
https://www.ncbi.nlm.nih.gov/pubmed/37715152
http://dx.doi.org/10.1186/s12887-023-04307-4
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