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Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

BACKGROUND: The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been limited due to technical challenges in isolating pure amyloid fibrils from brain e...

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Detalles Bibliográficos
Autores principales:	Upadhyay, Arun, Chhangani, Deepak, Rao, Nalini R., Kofler, Julia, Vassar, Robert, Rincon-Limas, Diego E., Savas, Jeffrey N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503190/ https://www.ncbi.nlm.nih.gov/pubmed/37710351 http://dx.doi.org/10.1186/s13024-023-00654-z

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