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Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease

BACKGROUND AND AIM: Circulating biomarkers of metabolic and cardiovascular diseases can help in the early detection and prevention of those diseases. Using proton nuclear magnetic resonance (1H-NMR), we aimed to study the plasma levels of low-molecular-weight metabolites (LMWMs) in a cohort of 307 p...

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Autores principales: Moreno-Vedia, Juan, Llop, Dídac, Rodríguez-Calvo, Ricardo, Plana, Núria, Amigó, Núria, Rosales, Roser, Esteban, Yaiza, Girona, Josefa, Masana, Lluís, Ibarretxe, Daiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503204/
https://www.ncbi.nlm.nih.gov/pubmed/37710233
http://dx.doi.org/10.1186/s12933-023-01958-6
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author Moreno-Vedia, Juan
Llop, Dídac
Rodríguez-Calvo, Ricardo
Plana, Núria
Amigó, Núria
Rosales, Roser
Esteban, Yaiza
Girona, Josefa
Masana, Lluís
Ibarretxe, Daiana
author_facet Moreno-Vedia, Juan
Llop, Dídac
Rodríguez-Calvo, Ricardo
Plana, Núria
Amigó, Núria
Rosales, Roser
Esteban, Yaiza
Girona, Josefa
Masana, Lluís
Ibarretxe, Daiana
author_sort Moreno-Vedia, Juan
collection PubMed
description BACKGROUND AND AIM: Circulating biomarkers of metabolic and cardiovascular diseases can help in the early detection and prevention of those diseases. Using proton nuclear magnetic resonance (1H-NMR), we aimed to study the plasma levels of low-molecular-weight metabolites (LMWMs) in a cohort of 307 patients with metabolic diseases to assess their relationships with type-2 diabetes (T2D) and incident atherosclerotic cardiovascular disease (ASCVD). METHODS: We conducted a cross-sectional and prospective study. We included 307 patients attending the Lipid Unit of our University Hospital for the treatment of the following metabolic disturbances and associated disorders: T2D (73.9%), obesity (58.7%), and hypertension (55.1%). 1H-NMR was used to study the plasma levels of 13 LMWMs. LMWM serum concentrations were evaluated in patients with and without T2D. and the correlations with several parameters and their associations with T2D were analyzed. The association between LMWM levels at baseline and the development of ASCVD in patients with T2D after 10 years of follow-up was also evaluated. RESULTS: Among the LMWMs measured, the branched-chain amino acids (BCAAs) valine, leucine and isoleucine showed a positive association with several clinical and lipid-related biochemical parameters and inflammatory markers (p < 0.05). Likewise, these three BCAAS were associated with diabetes even after adjusting for covariates (p < 0.05). During the follow-up period of 10 years, 29 of the 185 patients with diabetes at baseline (15.68%) developed ASCVD. After adjusting for clinical covariates, baseline levels of valine and alanine were associated with the development of ASCVD (p < 0.05). CONCLUSION: Overall, our results indicated that plasma levels of LMWMs measured by 1H-NMR could be potential biomarkers associated with T2D. Moreover, alanine and valine can help in the early detection of the cardiovascular risk associated with this metabolic disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-023-01958-6.
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spelling pubmed-105032042023-09-16 Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease Moreno-Vedia, Juan Llop, Dídac Rodríguez-Calvo, Ricardo Plana, Núria Amigó, Núria Rosales, Roser Esteban, Yaiza Girona, Josefa Masana, Lluís Ibarretxe, Daiana Cardiovasc Diabetol Research BACKGROUND AND AIM: Circulating biomarkers of metabolic and cardiovascular diseases can help in the early detection and prevention of those diseases. Using proton nuclear magnetic resonance (1H-NMR), we aimed to study the plasma levels of low-molecular-weight metabolites (LMWMs) in a cohort of 307 patients with metabolic diseases to assess their relationships with type-2 diabetes (T2D) and incident atherosclerotic cardiovascular disease (ASCVD). METHODS: We conducted a cross-sectional and prospective study. We included 307 patients attending the Lipid Unit of our University Hospital for the treatment of the following metabolic disturbances and associated disorders: T2D (73.9%), obesity (58.7%), and hypertension (55.1%). 1H-NMR was used to study the plasma levels of 13 LMWMs. LMWM serum concentrations were evaluated in patients with and without T2D. and the correlations with several parameters and their associations with T2D were analyzed. The association between LMWM levels at baseline and the development of ASCVD in patients with T2D after 10 years of follow-up was also evaluated. RESULTS: Among the LMWMs measured, the branched-chain amino acids (BCAAs) valine, leucine and isoleucine showed a positive association with several clinical and lipid-related biochemical parameters and inflammatory markers (p < 0.05). Likewise, these three BCAAS were associated with diabetes even after adjusting for covariates (p < 0.05). During the follow-up period of 10 years, 29 of the 185 patients with diabetes at baseline (15.68%) developed ASCVD. After adjusting for clinical covariates, baseline levels of valine and alanine were associated with the development of ASCVD (p < 0.05). CONCLUSION: Overall, our results indicated that plasma levels of LMWMs measured by 1H-NMR could be potential biomarkers associated with T2D. Moreover, alanine and valine can help in the early detection of the cardiovascular risk associated with this metabolic disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12933-023-01958-6. BioMed Central 2023-09-14 /pmc/articles/PMC10503204/ /pubmed/37710233 http://dx.doi.org/10.1186/s12933-023-01958-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Moreno-Vedia, Juan
Llop, Dídac
Rodríguez-Calvo, Ricardo
Plana, Núria
Amigó, Núria
Rosales, Roser
Esteban, Yaiza
Girona, Josefa
Masana, Lluís
Ibarretxe, Daiana
Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
title Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
title_full Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
title_fullStr Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
title_full_unstemmed Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
title_short Serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
title_sort serum branch-chained amino acids are increased in type 2 diabetes and associated with atherosclerotic cardiovascular disease
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503204/
https://www.ncbi.nlm.nih.gov/pubmed/37710233
http://dx.doi.org/10.1186/s12933-023-01958-6
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