Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart

To keep inflammatory bowel disease (IBD) in remission, mesalamine is frequently utilized. It primarily targets the inflammatory response and lowers prostaglandin and leukotriene synthesis. It can be applied topically, orally, or as a suppository. It is typically well tolerated, but occasionally it c...

Descripción completa

Detalles Bibliográficos
Autores principales: Chaudhry, Ahtshamullah, Noor, Jawad, Fatima, Ghulam, Batool, Saima, Noor, Riwad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503225/
https://www.ncbi.nlm.nih.gov/pubmed/37719567
http://dx.doi.org/10.7759/cureus.43567
_version_ 1785106482798264320
author Chaudhry, Ahtshamullah
Noor, Jawad
Fatima, Ghulam
Batool, Saima
Noor, Riwad
author_facet Chaudhry, Ahtshamullah
Noor, Jawad
Fatima, Ghulam
Batool, Saima
Noor, Riwad
author_sort Chaudhry, Ahtshamullah
collection PubMed
description To keep inflammatory bowel disease (IBD) in remission, mesalamine is frequently utilized. It primarily targets the inflammatory response and lowers prostaglandin and leukotriene synthesis. It can be applied topically, orally, or as a suppository. It is typically well tolerated, but occasionally it can cause serious side effects, leading to a variety of medical problems. We describe two cases of severe mesalamine-induced toxicity, one of which manifested as cardiomyopathy and the other as pneumonitis. However, early detection and treatment of the side effects can be lifesaving.
format Online
Article
Text
id pubmed-10503225
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-105032252023-09-16 Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart Chaudhry, Ahtshamullah Noor, Jawad Fatima, Ghulam Batool, Saima Noor, Riwad Cureus Internal Medicine To keep inflammatory bowel disease (IBD) in remission, mesalamine is frequently utilized. It primarily targets the inflammatory response and lowers prostaglandin and leukotriene synthesis. It can be applied topically, orally, or as a suppository. It is typically well tolerated, but occasionally it can cause serious side effects, leading to a variety of medical problems. We describe two cases of severe mesalamine-induced toxicity, one of which manifested as cardiomyopathy and the other as pneumonitis. However, early detection and treatment of the side effects can be lifesaving. Cureus 2023-08-16 /pmc/articles/PMC10503225/ /pubmed/37719567 http://dx.doi.org/10.7759/cureus.43567 Text en Copyright © 2023, Chaudhry et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Chaudhry, Ahtshamullah
Noor, Jawad
Fatima, Ghulam
Batool, Saima
Noor, Riwad
Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart
title Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart
title_full Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart
title_fullStr Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart
title_full_unstemmed Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart
title_short Mesalamine - A Revered Drug for Inflammatory Bowel Disease With Detrimental Effects on the Lung and Heart
title_sort mesalamine - a revered drug for inflammatory bowel disease with detrimental effects on the lung and heart
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503225/
https://www.ncbi.nlm.nih.gov/pubmed/37719567
http://dx.doi.org/10.7759/cureus.43567
work_keys_str_mv AT chaudhryahtshamullah mesalaminearevereddrugforinflammatoryboweldiseasewithdetrimentaleffectsonthelungandheart
AT noorjawad mesalaminearevereddrugforinflammatoryboweldiseasewithdetrimentaleffectsonthelungandheart
AT fatimaghulam mesalaminearevereddrugforinflammatoryboweldiseasewithdetrimentaleffectsonthelungandheart
AT batoolsaima mesalaminearevereddrugforinflammatoryboweldiseasewithdetrimentaleffectsonthelungandheart
AT noorriwad mesalaminearevereddrugforinflammatoryboweldiseasewithdetrimentaleffectsonthelungandheart

Ejemplares similares