A review of technological developments in lipid nanoparticle application for mRNA vaccination

Lipid nanoparticle (LNP) technology is critical to the advancement of mRNA vaccines. However, most studies focus on technical aspects and neglect the patent landscape. Moreover, there is a lack of differentiation of LNP technology differences among mRNA, mRNA vaccines, and COVID-19 mRNA vaccines, le...

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Detalles Bibliográficos
Autores principales: Yeh, Tzu-Fu, Lin, Chen, Sung, Huang-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503441/
https://www.ncbi.nlm.nih.gov/pubmed/37705354
http://dx.doi.org/10.1080/21645515.2023.2256040
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author Yeh, Tzu-Fu
Lin, Chen
Sung, Huang-Chih
author_facet Yeh, Tzu-Fu
Lin, Chen
Sung, Huang-Chih
author_sort Yeh, Tzu-Fu
collection PubMed
description Lipid nanoparticle (LNP) technology is critical to the advancement of mRNA vaccines. However, most studies focus on technical aspects and neglect the patent landscape. Moreover, there is a lack of differentiation of LNP technology differences among mRNA, mRNA vaccines, and COVID-19 mRNA vaccines, leading to confusing comparisons. This study fills this gap by analyzing LNP technology in academic journals and patents for mRNA, mRNA vaccines, and COVID-19 mRNA vaccines. The results show (1) academic impact on journal articles and patents, but no direct positive correlation; (2) the USA leads in academic research and patents, with China following closely; and (3) many cited articles have sponsors, indicating the importance of industry-university collaboration. This research aids strategic planning in government, academia, and industry, by providing trend analysis of LNP technology in journals and patents.
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spelling pubmed-105034412023-09-16 A review of technological developments in lipid nanoparticle application for mRNA vaccination Yeh, Tzu-Fu Lin, Chen Sung, Huang-Chih Hum Vaccin Immunother Review Lipid nanoparticle (LNP) technology is critical to the advancement of mRNA vaccines. However, most studies focus on technical aspects and neglect the patent landscape. Moreover, there is a lack of differentiation of LNP technology differences among mRNA, mRNA vaccines, and COVID-19 mRNA vaccines, leading to confusing comparisons. This study fills this gap by analyzing LNP technology in academic journals and patents for mRNA, mRNA vaccines, and COVID-19 mRNA vaccines. The results show (1) academic impact on journal articles and patents, but no direct positive correlation; (2) the USA leads in academic research and patents, with China following closely; and (3) many cited articles have sponsors, indicating the importance of industry-university collaboration. This research aids strategic planning in government, academia, and industry, by providing trend analysis of LNP technology in journals and patents. Taylor & Francis 2023-09-13 /pmc/articles/PMC10503441/ /pubmed/37705354 http://dx.doi.org/10.1080/21645515.2023.2256040 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Review
Yeh, Tzu-Fu
Lin, Chen
Sung, Huang-Chih
A review of technological developments in lipid nanoparticle application for mRNA vaccination
title A review of technological developments in lipid nanoparticle application for mRNA vaccination
title_full A review of technological developments in lipid nanoparticle application for mRNA vaccination
title_fullStr A review of technological developments in lipid nanoparticle application for mRNA vaccination
title_full_unstemmed A review of technological developments in lipid nanoparticle application for mRNA vaccination
title_short A review of technological developments in lipid nanoparticle application for mRNA vaccination
title_sort review of technological developments in lipid nanoparticle application for mrna vaccination
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503441/
https://www.ncbi.nlm.nih.gov/pubmed/37705354
http://dx.doi.org/10.1080/21645515.2023.2256040
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