Cargando…

Dyslipidemia and Nutritional Status of HIV-Infected Children and Adolescents on Antiretroviral Treatment at the Comprehensive Chronic Care and Training Center of Jimma Medical Center

BACKGROUND: Highly active antiretroviral treatment is beneficial to suppress human immune virus replication in infected individuals. However, dyslipidemia and other metabolic abnormalities have emerged due to antiretroviral treatment. The prevalence of dyslipidemia in children and adolescents on ant...

Descripción completa

Detalles Bibliográficos
Autores principales: Ambisa Lamesa, Tolera, Getachew Mamo, Aklilu, Arega Berihun, Gebeyaw, Alemu Kebede, Regassa, Bekele Lemesa, Eba, Cheneke Gebisa, Waqtola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503505/
https://www.ncbi.nlm.nih.gov/pubmed/37719174
http://dx.doi.org/10.2147/HIV.S418729
_version_ 1785106535340310528
author Ambisa Lamesa, Tolera
Getachew Mamo, Aklilu
Arega Berihun, Gebeyaw
Alemu Kebede, Regassa
Bekele Lemesa, Eba
Cheneke Gebisa, Waqtola
author_facet Ambisa Lamesa, Tolera
Getachew Mamo, Aklilu
Arega Berihun, Gebeyaw
Alemu Kebede, Regassa
Bekele Lemesa, Eba
Cheneke Gebisa, Waqtola
author_sort Ambisa Lamesa, Tolera
collection PubMed
description BACKGROUND: Highly active antiretroviral treatment is beneficial to suppress human immune virus replication in infected individuals. However, dyslipidemia and other metabolic abnormalities have emerged due to antiretroviral treatment. The prevalence of dyslipidemia in children and adolescents on antiretroviral treatment varies from 20% to 70%. The lack of data on children and adolescents in Ethiopia was the rationale for conducting this study. We aimed to determine prevalence of dyslipidemia and nutritional status in children and adolescents on follow-up at Jimma medical center. MATERIALS AND METHODS: A hospital-based cross-sectional study was conducted with 150 children and adolescents on follow-up at Jimma medical center. A systematic sampling technique was employed. An interview was carried out to collect socioeconomic and demographic data and a review of medical records was carried out to collect patients’ clinical data. Anthropometric data were computed using the CDC growth chart. About 3–5mL of fasting blood was collected to measure lipid profile. Multivariable logistic regression was performed to find the association between risk factors and lipid profile. RESULTS: The overall prevalence of dyslipidemia in this study was 72%. About 72% and 21.3% of study subjects had low high-density lipoprotein and high triglyceride, respectively. Significant associations were observed between BMI for age ≤5% (AOR: 2.02, 95% CI: 1.14–3.66; P=0.015) and low high-density lipoprotein; greater than 150 months on treatment (AOR: 1.02, 95% CI: 1.00–1.03; P=0.01) and high triglyceride; and BMI for age ≤5% (AOR: 1.86, 95% CI: 1.03–1.37; P=0.04) and high triglyceride. CONCLUSION: BMI for age <5%, treatment duration of greater than 150 months, and parents’ educational level were significantly associated with dyslipidemia, so it is recommended that monitoring of those variables will help to reduce dyslipidemia and its complications in children and adolescents receiving treatment.
format Online
Article
Text
id pubmed-10503505
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-105035052023-09-16 Dyslipidemia and Nutritional Status of HIV-Infected Children and Adolescents on Antiretroviral Treatment at the Comprehensive Chronic Care and Training Center of Jimma Medical Center Ambisa Lamesa, Tolera Getachew Mamo, Aklilu Arega Berihun, Gebeyaw Alemu Kebede, Regassa Bekele Lemesa, Eba Cheneke Gebisa, Waqtola HIV AIDS (Auckl) Original Research BACKGROUND: Highly active antiretroviral treatment is beneficial to suppress human immune virus replication in infected individuals. However, dyslipidemia and other metabolic abnormalities have emerged due to antiretroviral treatment. The prevalence of dyslipidemia in children and adolescents on antiretroviral treatment varies from 20% to 70%. The lack of data on children and adolescents in Ethiopia was the rationale for conducting this study. We aimed to determine prevalence of dyslipidemia and nutritional status in children and adolescents on follow-up at Jimma medical center. MATERIALS AND METHODS: A hospital-based cross-sectional study was conducted with 150 children and adolescents on follow-up at Jimma medical center. A systematic sampling technique was employed. An interview was carried out to collect socioeconomic and demographic data and a review of medical records was carried out to collect patients’ clinical data. Anthropometric data were computed using the CDC growth chart. About 3–5mL of fasting blood was collected to measure lipid profile. Multivariable logistic regression was performed to find the association between risk factors and lipid profile. RESULTS: The overall prevalence of dyslipidemia in this study was 72%. About 72% and 21.3% of study subjects had low high-density lipoprotein and high triglyceride, respectively. Significant associations were observed between BMI for age ≤5% (AOR: 2.02, 95% CI: 1.14–3.66; P=0.015) and low high-density lipoprotein; greater than 150 months on treatment (AOR: 1.02, 95% CI: 1.00–1.03; P=0.01) and high triglyceride; and BMI for age ≤5% (AOR: 1.86, 95% CI: 1.03–1.37; P=0.04) and high triglyceride. CONCLUSION: BMI for age <5%, treatment duration of greater than 150 months, and parents’ educational level were significantly associated with dyslipidemia, so it is recommended that monitoring of those variables will help to reduce dyslipidemia and its complications in children and adolescents receiving treatment. Dove 2023-09-11 /pmc/articles/PMC10503505/ /pubmed/37719174 http://dx.doi.org/10.2147/HIV.S418729 Text en © 2023 Ambisa Lamesa et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Ambisa Lamesa, Tolera
Getachew Mamo, Aklilu
Arega Berihun, Gebeyaw
Alemu Kebede, Regassa
Bekele Lemesa, Eba
Cheneke Gebisa, Waqtola
Dyslipidemia and Nutritional Status of HIV-Infected Children and Adolescents on Antiretroviral Treatment at the Comprehensive Chronic Care and Training Center of Jimma Medical Center
title Dyslipidemia and Nutritional Status of HIV-Infected Children and Adolescents on Antiretroviral Treatment at the Comprehensive Chronic Care and Training Center of Jimma Medical Center
title_full Dyslipidemia and Nutritional Status of HIV-Infected Children and Adolescents on Antiretroviral Treatment at the Comprehensive Chronic Care and Training Center of Jimma Medical Center
title_fullStr Dyslipidemia and Nutritional Status of HIV-Infected Children and Adolescents on Antiretroviral Treatment at the Comprehensive Chronic Care and Training Center of Jimma Medical Center
title_full_unstemmed Dyslipidemia and Nutritional Status of HIV-Infected Children and Adolescents on Antiretroviral Treatment at the Comprehensive Chronic Care and Training Center of Jimma Medical Center
title_short Dyslipidemia and Nutritional Status of HIV-Infected Children and Adolescents on Antiretroviral Treatment at the Comprehensive Chronic Care and Training Center of Jimma Medical Center
title_sort dyslipidemia and nutritional status of hiv-infected children and adolescents on antiretroviral treatment at the comprehensive chronic care and training center of jimma medical center
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503505/
https://www.ncbi.nlm.nih.gov/pubmed/37719174
http://dx.doi.org/10.2147/HIV.S418729
work_keys_str_mv AT ambisalamesatolera dyslipidemiaandnutritionalstatusofhivinfectedchildrenandadolescentsonantiretroviraltreatmentatthecomprehensivechroniccareandtrainingcenterofjimmamedicalcenter
AT getachewmamoaklilu dyslipidemiaandnutritionalstatusofhivinfectedchildrenandadolescentsonantiretroviraltreatmentatthecomprehensivechroniccareandtrainingcenterofjimmamedicalcenter
AT aregaberihungebeyaw dyslipidemiaandnutritionalstatusofhivinfectedchildrenandadolescentsonantiretroviraltreatmentatthecomprehensivechroniccareandtrainingcenterofjimmamedicalcenter
AT alemukebederegassa dyslipidemiaandnutritionalstatusofhivinfectedchildrenandadolescentsonantiretroviraltreatmentatthecomprehensivechroniccareandtrainingcenterofjimmamedicalcenter
AT bekelelemesaeba dyslipidemiaandnutritionalstatusofhivinfectedchildrenandadolescentsonantiretroviraltreatmentatthecomprehensivechroniccareandtrainingcenterofjimmamedicalcenter
AT chenekegebisawaqtola dyslipidemiaandnutritionalstatusofhivinfectedchildrenandadolescentsonantiretroviraltreatmentatthecomprehensivechroniccareandtrainingcenterofjimmamedicalcenter