Genome Analysis of ST1 Bartonella henselae, a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China

Infective endocarditis (IE) is a rare disease but with high associated mortality. Currently, the mainstays of diagnosis are still echocardiography and blood cultures. Here, we reported a case of infective endocarditis with negative blood cultures, and blood and aortic valve tissue metagenomic next-g...

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Autores principales: Mu, Xinli, Liang, Jianghong, Qian, Linyan, Zhou, Bing, Zou, Xuehan, Fu, Ying, Zhu, Yongze, Li, Xi, Shi, Jiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503507/
https://www.ncbi.nlm.nih.gov/pubmed/37719652
http://dx.doi.org/10.2147/IDR.S422345
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author Mu, Xinli
Liang, Jianghong
Qian, Linyan
Zhou, Bing
Zou, Xuehan
Fu, Ying
Zhu, Yongze
Li, Xi
Shi, Jiana
author_facet Mu, Xinli
Liang, Jianghong
Qian, Linyan
Zhou, Bing
Zou, Xuehan
Fu, Ying
Zhu, Yongze
Li, Xi
Shi, Jiana
author_sort Mu, Xinli
collection PubMed
description Infective endocarditis (IE) is a rare disease but with high associated mortality. Currently, the mainstays of diagnosis are still echocardiography and blood cultures. Here, we reported a case of infective endocarditis with negative blood cultures, and blood and aortic valve tissue metagenomic next-generation sequencing (mNGS) results suggested Bartonella henselae. In addition, we obtained the whole genomic sequence of B. henselae ZJBH strain. To our knowledge, this is the first report of B. henselae genomic analysis isolated from clinic in China. Furthermore, we described the whole genome sequencing (WGS) data incorporating all B. henselae from diverse sources worldwide and shed light on underlying risk of B. henselae transmitted between cats and humans.
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spelling pubmed-105035072023-09-16 Genome Analysis of ST1 Bartonella henselae, a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China Mu, Xinli Liang, Jianghong Qian, Linyan Zhou, Bing Zou, Xuehan Fu, Ying Zhu, Yongze Li, Xi Shi, Jiana Infect Drug Resist Case Report Infective endocarditis (IE) is a rare disease but with high associated mortality. Currently, the mainstays of diagnosis are still echocardiography and blood cultures. Here, we reported a case of infective endocarditis with negative blood cultures, and blood and aortic valve tissue metagenomic next-generation sequencing (mNGS) results suggested Bartonella henselae. In addition, we obtained the whole genomic sequence of B. henselae ZJBH strain. To our knowledge, this is the first report of B. henselae genomic analysis isolated from clinic in China. Furthermore, we described the whole genome sequencing (WGS) data incorporating all B. henselae from diverse sources worldwide and shed light on underlying risk of B. henselae transmitted between cats and humans. Dove 2023-09-11 /pmc/articles/PMC10503507/ /pubmed/37719652 http://dx.doi.org/10.2147/IDR.S422345 Text en © 2023 Mu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Mu, Xinli
Liang, Jianghong
Qian, Linyan
Zhou, Bing
Zou, Xuehan
Fu, Ying
Zhu, Yongze
Li, Xi
Shi, Jiana
Genome Analysis of ST1 Bartonella henselae, a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China
title Genome Analysis of ST1 Bartonella henselae, a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China
title_full Genome Analysis of ST1 Bartonella henselae, a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China
title_fullStr Genome Analysis of ST1 Bartonella henselae, a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China
title_full_unstemmed Genome Analysis of ST1 Bartonella henselae, a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China
title_short Genome Analysis of ST1 Bartonella henselae, a Zoonotic Pathogen Causing Endocarditis in an Elderly Patient in China
title_sort genome analysis of st1 bartonella henselae, a zoonotic pathogen causing endocarditis in an elderly patient in china
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503507/
https://www.ncbi.nlm.nih.gov/pubmed/37719652
http://dx.doi.org/10.2147/IDR.S422345
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