Cargando…

Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease. The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein. Among the multiple causes of tau hyperph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Medina-Vera, Dina, López-Gambero, Antonio Jesús, Navarro, Juan Antonio, Sanjuan, Carlos, Baixeras, Elena, Decara, Juan, de Fonseca, Fernando Rodríguez
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503604/ https://www.ncbi.nlm.nih.gov/pubmed/37488880 http://dx.doi.org/10.4103/1673-5374.379015

Ejemplares similares

d‐Pinitol promotes tau dephosphorylation through a cyclin‐dependent kinase 5 regulation mechanism: A new potential approach for tauopathies?
por: Medina‐Vera, Dina, et al.
Publicado: (2022)

Pharmacokinetics and Endocrine Effects of an Oral Dose of D-Pinitol in Human Fasting Healthy Volunteers
por: Navarro, Juan A., et al.
Publicado: (2022)

Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes
por: Navarro, Juan A., et al.
Publicado: (2022)

D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats
por: Navarro, Juan A., et al.
Publicado: (2020)

Activation of PI3K/Akt Signaling Pathway in Rat Hypothalamus Induced by an Acute Oral Administration of D-Pinitol
por: Medina-Vera, Dina, et al.
Publicado: (2021)

Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases
por: Decara, Juan, et al.
Publicado: (2020)

A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse
por: López-Gambero, Antonio J., et al.
Publicado: (2021)

Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
por: Wan, Wenbin, et al.
Publicado: (2019)

Hyperphosphorylation-Induced Tau Oligomers
por: Iqbal, Khalid, et al.
Publicado: (2013)

Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2016)

The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats
por: Decara, Juan, et al.
Publicado: (2018)

Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau
por: Taylor, Henry B.C., et al.
Publicado: (2021)

D-Pinitol—Active Natural Product from Carob with Notable Insulin Regulation
por: Azab, Abdullatif
Publicado: (2022)

Corrigendum: Evidence of Tau Hyperphosphorylation and Dystrophic Microglia in the Common Marmoset
por: Rodriguez-Callejas, Juan D., et al.
Publicado: (2017)

The Link Between Diabetes Mellitus and Tau Hyperphosphorylation: Implications for Risk of Alzheimer's Disease
por: Hobday, Amy L, et al.
Publicado: (2021)

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
por: Melov, Simon, et al.
Publicado: (2007)

Hyperphosphorylated tau in young and middle-aged subjects
por: Elobeid, Adila, et al.
Publicado: (2011)

PINCH in the Cellular Stress Response to Tau-Hyperphosphorylation
por: Ozdemir, Ahmet Yunus, et al.
Publicado: (2013)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Immunological memory to hyperphosphorylated tau in asymptomatic individuals
por: Pascual, Gabriel, et al.
Publicado: (2017)

Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer’s Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated
por: Barthélemy, Nicolas R., et al.
Publicado: (2022)

Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease
por: Borin, Mirta, et al.
Publicado: (2018)

Zinc Binding Directly Regulates Tau Toxicity Independent of Tau Hyperphosphorylation
por: Huang, Yunpeng, et al.
Publicado: (2014)

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases
por: López-Gambero, Antonio J., et al.
Publicado: (2020)

Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice
por: Chen, Yanxing, et al.
Publicado: (2014)

Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Drosophila Model of Tauopathy and Neuroblastoma Cells
por: Chatterjee, Shreyasi, et al.
Publicado: (2019)

Amelioration of Hippocampal Insulin Resistance Reduces Tau Hyperphosphorylation and Cognitive Decline Induced by Isoflurane in Mice
por: Peng, Liangyu, et al.
Publicado: (2021)

Hyperphosphorylation and Cleavage at D421 Enhance Tau Secretion
por: Plouffe, Vanessa, et al.
Publicado: (2012)

Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss
por: Tiwari, Sachin Suresh, et al.
Publicado: (2016)

Kainic acid hyperphosphorylates tau via inflammasome activation in MAPT transgenic mice
por: Zheng, Xiang-Yu, et al.
Publicado: (2019)

Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases
por: Duka, Valeriy, et al.
Publicado: (2013)

Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology
por: Gratuze, Maud, et al.
Publicado: (2017)

Dimethyl Sulfoxide Induces Both Direct and Indirect Tau Hyperphosphorylation
por: Julien, Carl, et al.
Publicado: (2012)

Betaine Alleviates Hypertriglycemia and Tau Hyperphosphorylation in db/db Mice
por: Jung, Ga-young, et al.
Publicado: (2013)

Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
por: Liu, Jin, et al.
Publicado: (2016)

Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer’s disease
por: Ivanov, Stefan M., et al.
Publicado: (2020)

Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid
por: Foidl, Bettina M., et al.
Publicado: (2018)

Imbalance of Endocannabinoid/Lysophosphatidylinositol Receptors Marks the Severity of Alzheimer’s Disease in a Preclinical Model: A Therapeutic Opportunity
por: Medina-Vera, Dina, et al.
Publicado: (2020)

Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions
por: Liu, Mengyu, et al.
Publicado: (2020)

Codonopsis pilosula Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice
por: Zhang, Qing, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t3naq68h2deqnjqdoabji5f6t7