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Physiological and pathological functions of circular RNAs in the nervous system

Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and tissues. CircRNAs play crucial roles in physiological and pathological processes by sponging microRNAs, modulating gene transcription, controlling the activi...

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Autores principales: Zhou, Min, Li, Shi, Huang, Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503630/
https://www.ncbi.nlm.nih.gov/pubmed/37488888
http://dx.doi.org/10.4103/1673-5374.379017
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author Zhou, Min
Li, Shi
Huang, Chuan
author_facet Zhou, Min
Li, Shi
Huang, Chuan
author_sort Zhou, Min
collection PubMed
description Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and tissues. CircRNAs play crucial roles in physiological and pathological processes by sponging microRNAs, modulating gene transcription, controlling the activity of certain RNA-binding proteins, and producing functional peptides. A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 years. However, the precise role of circRNAs in the nervous system has yet to be comprehensively reviewed. In this review, we first summarize the recently described roles of circRNAs in brain development, maturity, and aging. Then, we focus on the involvement of circRNAs in various diseases of the central nervous system, such as brain cancer, chronic neurodegenerative diseases, acute injuries of the nervous system, and neuropathic pain. A better understanding of the functionality of circRNAs will help us to develop potential diagnostic, prognostic, and therapeutic strategies to treat diseases of the nervous system.
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spelling pubmed-105036302023-09-16 Physiological and pathological functions of circular RNAs in the nervous system Zhou, Min Li, Shi Huang, Chuan Neural Regen Res Review Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and tissues. CircRNAs play crucial roles in physiological and pathological processes by sponging microRNAs, modulating gene transcription, controlling the activity of certain RNA-binding proteins, and producing functional peptides. A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 years. However, the precise role of circRNAs in the nervous system has yet to be comprehensively reviewed. In this review, we first summarize the recently described roles of circRNAs in brain development, maturity, and aging. Then, we focus on the involvement of circRNAs in various diseases of the central nervous system, such as brain cancer, chronic neurodegenerative diseases, acute injuries of the nervous system, and neuropathic pain. A better understanding of the functionality of circRNAs will help us to develop potential diagnostic, prognostic, and therapeutic strategies to treat diseases of the nervous system. Wolters Kluwer - Medknow 2023-07-07 /pmc/articles/PMC10503630/ /pubmed/37488888 http://dx.doi.org/10.4103/1673-5374.379017 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Zhou, Min
Li, Shi
Huang, Chuan
Physiological and pathological functions of circular RNAs in the nervous system
title Physiological and pathological functions of circular RNAs in the nervous system
title_full Physiological and pathological functions of circular RNAs in the nervous system
title_fullStr Physiological and pathological functions of circular RNAs in the nervous system
title_full_unstemmed Physiological and pathological functions of circular RNAs in the nervous system
title_short Physiological and pathological functions of circular RNAs in the nervous system
title_sort physiological and pathological functions of circular rnas in the nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503630/
https://www.ncbi.nlm.nih.gov/pubmed/37488888
http://dx.doi.org/10.4103/1673-5374.379017
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