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In vivo CRISPR screen identifies LTN1 as a novel tumor suppressor ubiquitinating insulin–like growth factor 2 mRNA–binding protein 1 in hepatocellular carcinoma

BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is a frequent and aggressive kind of cancer. Although E3 ligases play important roles in HCC development, several E3 ligases remain unknown. APPROACH AND RESULTS: Through in vivo CRISPR knockout (KO) screens targeting related E3 ligase genes in HCC...

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Detalles Bibliográficos
Autores principales:	Peng, Rui, Cao, Jun, Zhang, Chi, Zhou, Jie, Su, Bing-Bing, Tu, Dao-Yuan, Jiang, Guo-Qing, Jin, Sheng-Jie, Xu, Ya-Ping, Bai, Dou-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503668/ https://www.ncbi.nlm.nih.gov/pubmed/37708447 http://dx.doi.org/10.1097/HC9.0000000000000256

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