Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation

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Kaposi’s sarcoma-associated herpesvirus (KSHV) causes several human diseases including Kaposi’s sarcoma (KS), a leading cause of cancer in Africa and in patients with AIDS. KS tumor cells harbor KSHV predominantly in a latent form, while typically <5% contain lytic replicating virus. Because both...

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Detalles Bibliográficos
Autores principales: Olson, Annabel T., Kang, Yuqi, Ladha, Anushka M., Zhu, Songli, Lim, Chuan Bian, Nabet, Behnam, Lagunoff, Michael, Gujral, Taranjit S., Geballe, Adam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503724/
https://www.ncbi.nlm.nih.gov/pubmed/37669313
http://dx.doi.org/10.1371/journal.ppat.1011169

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