Cargando…
Coxsackievirus B3 elicits a sex-specific CD8(+) T cell response which protects female mice
Sex is a significant contributor to the outcome of human infections. Males are frequently more susceptible to viral, bacterial, and fungal infections, often attributed to weaker immune responses. In contrast, a heightened immune response in females enables better pathogen elimination but leaves fema...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503745/ https://www.ncbi.nlm.nih.gov/pubmed/37669302 http://dx.doi.org/10.1371/journal.ppat.1011465 |
_version_ | 1785106586364018688 |
---|---|
author | Dhalech, Adeeba H. Condotta, Stephanie A. Pattnaik, Aryamav Corn, Caleb Richer, Martin J. Robinson, Christopher M. |
author_facet | Dhalech, Adeeba H. Condotta, Stephanie A. Pattnaik, Aryamav Corn, Caleb Richer, Martin J. Robinson, Christopher M. |
author_sort | Dhalech, Adeeba H. |
collection | PubMed |
description | Sex is a significant contributor to the outcome of human infections. Males are frequently more susceptible to viral, bacterial, and fungal infections, often attributed to weaker immune responses. In contrast, a heightened immune response in females enables better pathogen elimination but leaves females more predisposed to autoimmune diseases. Unfortunately, the underlying basis for sex-specific immune responses remains poorly understood. Here, we show a sex difference in the CD8(+) T cell response to an enteric virus, Coxsackievirus B3 (CVB3). We found that CVB3 induced expansion of CD8(+) T cells in female mice but not in male mice. CVB3 also increased the proportion and number of CD11a(hi)CD62L(lo) CD8(+) T cells in female mice, indicative of activation. This response was independent of the inoculation route and type I interferon. Using a recombinant CVB3 virus expressing a model CD8(+) T cell epitope, we found that the expansion of CD8(+) T cells in females is viral-specific and not due to bystander activation. Finally, the depletion of CD8(+) T cells, prior to infection, led to enhanced mortality, indicating that CD8(+) T cells are protective against CVB3 in female mice. These data demonstrate that CVB3 induces a CD8(+) T cell response in female mice and highlight the importance of sex-specific immune responses to viral pathogens. |
format | Online Article Text |
id | pubmed-10503745 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-105037452023-09-16 Coxsackievirus B3 elicits a sex-specific CD8(+) T cell response which protects female mice Dhalech, Adeeba H. Condotta, Stephanie A. Pattnaik, Aryamav Corn, Caleb Richer, Martin J. Robinson, Christopher M. PLoS Pathog Research Article Sex is a significant contributor to the outcome of human infections. Males are frequently more susceptible to viral, bacterial, and fungal infections, often attributed to weaker immune responses. In contrast, a heightened immune response in females enables better pathogen elimination but leaves females more predisposed to autoimmune diseases. Unfortunately, the underlying basis for sex-specific immune responses remains poorly understood. Here, we show a sex difference in the CD8(+) T cell response to an enteric virus, Coxsackievirus B3 (CVB3). We found that CVB3 induced expansion of CD8(+) T cells in female mice but not in male mice. CVB3 also increased the proportion and number of CD11a(hi)CD62L(lo) CD8(+) T cells in female mice, indicative of activation. This response was independent of the inoculation route and type I interferon. Using a recombinant CVB3 virus expressing a model CD8(+) T cell epitope, we found that the expansion of CD8(+) T cells in females is viral-specific and not due to bystander activation. Finally, the depletion of CD8(+) T cells, prior to infection, led to enhanced mortality, indicating that CD8(+) T cells are protective against CVB3 in female mice. These data demonstrate that CVB3 induces a CD8(+) T cell response in female mice and highlight the importance of sex-specific immune responses to viral pathogens. Public Library of Science 2023-09-05 /pmc/articles/PMC10503745/ /pubmed/37669302 http://dx.doi.org/10.1371/journal.ppat.1011465 Text en © 2023 Dhalech et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Dhalech, Adeeba H. Condotta, Stephanie A. Pattnaik, Aryamav Corn, Caleb Richer, Martin J. Robinson, Christopher M. Coxsackievirus B3 elicits a sex-specific CD8(+) T cell response which protects female mice |
title | Coxsackievirus B3 elicits a sex-specific CD8(+) T cell response which protects female mice |
title_full | Coxsackievirus B3 elicits a sex-specific CD8(+) T cell response which protects female mice |
title_fullStr | Coxsackievirus B3 elicits a sex-specific CD8(+) T cell response which protects female mice |
title_full_unstemmed | Coxsackievirus B3 elicits a sex-specific CD8(+) T cell response which protects female mice |
title_short | Coxsackievirus B3 elicits a sex-specific CD8(+) T cell response which protects female mice |
title_sort | coxsackievirus b3 elicits a sex-specific cd8(+) t cell response which protects female mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503745/ https://www.ncbi.nlm.nih.gov/pubmed/37669302 http://dx.doi.org/10.1371/journal.ppat.1011465 |
work_keys_str_mv | AT dhalechadeebah coxsackievirusb3elicitsasexspecificcd8tcellresponsewhichprotectsfemalemice AT condottastephaniea coxsackievirusb3elicitsasexspecificcd8tcellresponsewhichprotectsfemalemice AT pattnaikaryamav coxsackievirusb3elicitsasexspecificcd8tcellresponsewhichprotectsfemalemice AT corncaleb coxsackievirusb3elicitsasexspecificcd8tcellresponsewhichprotectsfemalemice AT richermartinj coxsackievirusb3elicitsasexspecificcd8tcellresponsewhichprotectsfemalemice AT robinsonchristopherm coxsackievirusb3elicitsasexspecificcd8tcellresponsewhichprotectsfemalemice |