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Tumors recycle glucocorticoids to drive Treg-mediated immunosuppression

Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by the adrenals, can be reconverted from their inactive form to ac...

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Detalles Bibliográficos
Autores principales: Swatler, Julian, Ju, Young-Jun, Anderson, Ana C., Lugli, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503790/
https://www.ncbi.nlm.nih.gov/pubmed/37712416
http://dx.doi.org/10.1172/JCI173141