The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes

Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, and Black individuals have a higher incidence of isc...

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Detalles Bibliográficos
Autores principales: Denorme, Frederik, Armstrong, Nicole D., Stoller, Michelle L., Portier, Irina, Tugolukova, Emilia A., Tanner, Rikki M., Montenont, Emilie, Bhatlekar, Seema, Cody, Mark, Rustad, John L., Ajanel, Abigail, Tolley, Neal D., Murray, Darian C., Boyle, Julie L., Nieman, Marvin T., McKenzie, Steven E., Yost, Christian Con, Lange, Leslie A., Cushman, Mary, Irvin, Marguerite R., Bray, Paul F., Campbell, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503801/
https://www.ncbi.nlm.nih.gov/pubmed/37471144
http://dx.doi.org/10.1172/JCI169608

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