Genetic modification of inflammation- and clonal hematopoiesis–associated cardiovascular risk

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVDs), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 424,651 UK Biobank participants. We identified CHIP...

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Detalles Bibliográficos
Autores principales: Yu, Zhi, Fidler, Trevor P., Ruan, Yunfeng, Vlasschaert, Caitlyn, Nakao, Tetsushi, Uddin, Md Mesbah, Mack, Taralynn, Niroula, Abhishek, Heimlich, J. Brett, Zekavat, Seyedeh M., Gibson, Christopher J., Griffin, Gabriel K., Wang, Yuxuan, Peloso, Gina M., Heard-Costa, Nancy, Levy, Daniel, Vasan, Ramachandran S., Aguet, François, Ardlie, Kristin G., Taylor, Kent D., Rich, Stephen S., Rotter, Jerome I., Libby, Peter, Jaiswal, Siddhartha, Ebert, Benjamin L., Bick, Alexander G., Tall, Alan R., Natarajan, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503804/
https://www.ncbi.nlm.nih.gov/pubmed/37498674
http://dx.doi.org/10.1172/JCI168597

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