3,3-dimethyl-1-butanol and its metabolite 3,3-dimethylbutyrate ameliorate collagen-induced arthritis independent of choline trimethylamine lyase activity

Previous studies have identified significant alterations in intestinal carnitine metabolism in mice with collagen-induced arthritis (CIA), potentially linking bacterial dysbiosis with autoimmunity. Bacterial trimethylamine (TMA) lyases metabolize dietary carnitine to TMA, which is oxidized in the li...

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Detalles Bibliográficos
Autores principales: Fechtner, Sabrina, Allen, Brendan E., Chriswell, Meagan E., Jubair, Widian K., Robertson, Charles E., Kofonow, Jennifer N., Frank, Daniel N., Holers, V. Michael, Kuhn, Kristine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503834/
https://www.ncbi.nlm.nih.gov/pubmed/37720032
http://dx.doi.org/10.21203/rs.3.rs-3297018/v1

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