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Biomimetic Gland Models with Engineered Stratagems
As extensively distributed tissues throughout the human body, glands play a critical role in various physiological processes. Therefore, the construction of biomimetic gland models in vitro has aroused great interest in multiple disciplines. In the biological field, the researchers focus on optimizi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AAAS
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503994/ https://www.ncbi.nlm.nih.gov/pubmed/37719047 http://dx.doi.org/10.34133/research.0232 |
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author | Lin, Xiang Sun, Lingyu Lu, Minhui Zhao, Yuanjin |
author_facet | Lin, Xiang Sun, Lingyu Lu, Minhui Zhao, Yuanjin |
author_sort | Lin, Xiang |
collection | PubMed |
description | As extensively distributed tissues throughout the human body, glands play a critical role in various physiological processes. Therefore, the construction of biomimetic gland models in vitro has aroused great interest in multiple disciplines. In the biological field, the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands, such as the emergence of organoid technology. From the perspective of biomedical engineering, the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics, to mimic the in vivo environment of glandular tissues. These engineered stratagems endowed gland models with more biomimetic features, as well as a wide range of application prospects. In this review, we first describe the biomimetic strategies for constructing different in vitro gland models, focusing on the role of microfluidics in promoting the structure and function development of biomimetic glands. After summarizing several common in vitro models of endocrine and exocrine glands, the applications of gland models in disease modelling, drug screening, regenerative medicine, and personalized medicine are enumerated. Finally, we conclude the current challenges and our perspective of these biomimetic gland models. |
format | Online Article Text |
id | pubmed-10503994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | AAAS |
record_format | MEDLINE/PubMed |
spelling | pubmed-105039942023-09-16 Biomimetic Gland Models with Engineered Stratagems Lin, Xiang Sun, Lingyu Lu, Minhui Zhao, Yuanjin Research (Wash D C) Review Article As extensively distributed tissues throughout the human body, glands play a critical role in various physiological processes. Therefore, the construction of biomimetic gland models in vitro has aroused great interest in multiple disciplines. In the biological field, the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands, such as the emergence of organoid technology. From the perspective of biomedical engineering, the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics, to mimic the in vivo environment of glandular tissues. These engineered stratagems endowed gland models with more biomimetic features, as well as a wide range of application prospects. In this review, we first describe the biomimetic strategies for constructing different in vitro gland models, focusing on the role of microfluidics in promoting the structure and function development of biomimetic glands. After summarizing several common in vitro models of endocrine and exocrine glands, the applications of gland models in disease modelling, drug screening, regenerative medicine, and personalized medicine are enumerated. Finally, we conclude the current challenges and our perspective of these biomimetic gland models. AAAS 2023-09-15 /pmc/articles/PMC10503994/ /pubmed/37719047 http://dx.doi.org/10.34133/research.0232 Text en Copyright © 2023 Xiang Lin et al. https://creativecommons.org/licenses/by/4.0/Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Lin, Xiang Sun, Lingyu Lu, Minhui Zhao, Yuanjin Biomimetic Gland Models with Engineered Stratagems |
title | Biomimetic Gland Models with Engineered Stratagems |
title_full | Biomimetic Gland Models with Engineered Stratagems |
title_fullStr | Biomimetic Gland Models with Engineered Stratagems |
title_full_unstemmed | Biomimetic Gland Models with Engineered Stratagems |
title_short | Biomimetic Gland Models with Engineered Stratagems |
title_sort | biomimetic gland models with engineered stratagems |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503994/ https://www.ncbi.nlm.nih.gov/pubmed/37719047 http://dx.doi.org/10.34133/research.0232 |
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