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Biomimetic Gland Models with Engineered Stratagems

As extensively distributed tissues throughout the human body, glands play a critical role in various physiological processes. Therefore, the construction of biomimetic gland models in vitro has aroused great interest in multiple disciplines. In the biological field, the researchers focus on optimizi...

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Detalles Bibliográficos
Autores principales: Lin, Xiang, Sun, Lingyu, Lu, Minhui, Zhao, Yuanjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503994/
https://www.ncbi.nlm.nih.gov/pubmed/37719047
http://dx.doi.org/10.34133/research.0232
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author Lin, Xiang
Sun, Lingyu
Lu, Minhui
Zhao, Yuanjin
author_facet Lin, Xiang
Sun, Lingyu
Lu, Minhui
Zhao, Yuanjin
author_sort Lin, Xiang
collection PubMed
description As extensively distributed tissues throughout the human body, glands play a critical role in various physiological processes. Therefore, the construction of biomimetic gland models in vitro has aroused great interest in multiple disciplines. In the biological field, the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands, such as the emergence of organoid technology. From the perspective of biomedical engineering, the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics, to mimic the in vivo environment of glandular tissues. These engineered stratagems endowed gland models with more biomimetic features, as well as a wide range of application prospects. In this review, we first describe the biomimetic strategies for constructing different in vitro gland models, focusing on the role of microfluidics in promoting the structure and function development of biomimetic glands. After summarizing several common in vitro models of endocrine and exocrine glands, the applications of gland models in disease modelling, drug screening, regenerative medicine, and personalized medicine are enumerated. Finally, we conclude the current challenges and our perspective of these biomimetic gland models.
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spelling pubmed-105039942023-09-16 Biomimetic Gland Models with Engineered Stratagems Lin, Xiang Sun, Lingyu Lu, Minhui Zhao, Yuanjin Research (Wash D C) Review Article As extensively distributed tissues throughout the human body, glands play a critical role in various physiological processes. Therefore, the construction of biomimetic gland models in vitro has aroused great interest in multiple disciplines. In the biological field, the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands, such as the emergence of organoid technology. From the perspective of biomedical engineering, the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics, to mimic the in vivo environment of glandular tissues. These engineered stratagems endowed gland models with more biomimetic features, as well as a wide range of application prospects. In this review, we first describe the biomimetic strategies for constructing different in vitro gland models, focusing on the role of microfluidics in promoting the structure and function development of biomimetic glands. After summarizing several common in vitro models of endocrine and exocrine glands, the applications of gland models in disease modelling, drug screening, regenerative medicine, and personalized medicine are enumerated. Finally, we conclude the current challenges and our perspective of these biomimetic gland models. AAAS 2023-09-15 /pmc/articles/PMC10503994/ /pubmed/37719047 http://dx.doi.org/10.34133/research.0232 Text en Copyright © 2023 Xiang Lin et al. https://creativecommons.org/licenses/by/4.0/Exclusive licensee Science and Technology Review Publishing House. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Lin, Xiang
Sun, Lingyu
Lu, Minhui
Zhao, Yuanjin
Biomimetic Gland Models with Engineered Stratagems
title Biomimetic Gland Models with Engineered Stratagems
title_full Biomimetic Gland Models with Engineered Stratagems
title_fullStr Biomimetic Gland Models with Engineered Stratagems
title_full_unstemmed Biomimetic Gland Models with Engineered Stratagems
title_short Biomimetic Gland Models with Engineered Stratagems
title_sort biomimetic gland models with engineered stratagems
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503994/
https://www.ncbi.nlm.nih.gov/pubmed/37719047
http://dx.doi.org/10.34133/research.0232
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