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All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction

Malignant central airway obstruction (MCAO) resulting from tumor metastasis and compression severely impairs respiration, posing life-threatening risks. To address this, we employed a synergistic modification strategy, combining cisplatin (CIS) and silver nanoparticles (AgNPs). Polycaprolactone (PCL...

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Autores principales: Li, Zhaonan, Zhang, Wenguang, Jiao, Dechao, Tian, Chuan, Xu, Kaihao, Zhu, Haidong, Han, Xinwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503995/
https://www.ncbi.nlm.nih.gov/pubmed/37719298
http://dx.doi.org/10.1063/5.0157341
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author Li, Zhaonan
Zhang, Wenguang
Jiao, Dechao
Tian, Chuan
Xu, Kaihao
Zhu, Haidong
Han, Xinwei
author_facet Li, Zhaonan
Zhang, Wenguang
Jiao, Dechao
Tian, Chuan
Xu, Kaihao
Zhu, Haidong
Han, Xinwei
author_sort Li, Zhaonan
collection PubMed
description Malignant central airway obstruction (MCAO) resulting from tumor metastasis and compression severely impairs respiration, posing life-threatening risks. To address this, we employed a synergistic modification strategy, combining cisplatin (CIS) and silver nanoparticles (AgNPs). Polycaprolactone (PCL) served as a drug carrier, enabling the preparation of a functional CIS@AgNPs@PCL fiber membrane-covered airway stent via electrospinning. This approach aimed to enhance the patency rate of MCAO. Characterization via ATR-FTIR, scanning electron microscope-energy-dispersive spectroscopy, and transmission electron microscope confirmed successful immobilization of CIS and AgNPs onto the stent surface. CIS@AgNPs@PCL substantially suppressed non-small cell lung cancer cells (A549), causing DNA damage, ultrastructural disruption, and over 50% apoptosis in 48 h. It also displayed potent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans biofilms. A mouse subcutaneous tumor recurrence model assessed anti-cancer efficacy. CIS@AgNPs@PCL fiber-covered stents significantly inhibited lung cancer tissue and enhanced anti-cancer effects by up-regulating caspase-3 and Bax, while down-regulating Bcl-2. This study's functional airway stent provides a proof-of-concept for an integrated anti-cancer and antibacterial strategy. It promptly restores the lumen, inhibits biofilm formation, prevents tumor progression, and improves postoperative MCAO patency.
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spelling pubmed-105039952023-09-16 All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction Li, Zhaonan Zhang, Wenguang Jiao, Dechao Tian, Chuan Xu, Kaihao Zhu, Haidong Han, Xinwei APL Bioeng Articles Malignant central airway obstruction (MCAO) resulting from tumor metastasis and compression severely impairs respiration, posing life-threatening risks. To address this, we employed a synergistic modification strategy, combining cisplatin (CIS) and silver nanoparticles (AgNPs). Polycaprolactone (PCL) served as a drug carrier, enabling the preparation of a functional CIS@AgNPs@PCL fiber membrane-covered airway stent via electrospinning. This approach aimed to enhance the patency rate of MCAO. Characterization via ATR-FTIR, scanning electron microscope-energy-dispersive spectroscopy, and transmission electron microscope confirmed successful immobilization of CIS and AgNPs onto the stent surface. CIS@AgNPs@PCL substantially suppressed non-small cell lung cancer cells (A549), causing DNA damage, ultrastructural disruption, and over 50% apoptosis in 48 h. It also displayed potent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans biofilms. A mouse subcutaneous tumor recurrence model assessed anti-cancer efficacy. CIS@AgNPs@PCL fiber-covered stents significantly inhibited lung cancer tissue and enhanced anti-cancer effects by up-regulating caspase-3 and Bax, while down-regulating Bcl-2. This study's functional airway stent provides a proof-of-concept for an integrated anti-cancer and antibacterial strategy. It promptly restores the lumen, inhibits biofilm formation, prevents tumor progression, and improves postoperative MCAO patency. AIP Publishing LLC 2023-09-13 /pmc/articles/PMC10503995/ /pubmed/37719298 http://dx.doi.org/10.1063/5.0157341 Text en © 2023 Author(s). https://creativecommons.org/licenses/by/4.0/All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Articles
Li, Zhaonan
Zhang, Wenguang
Jiao, Dechao
Tian, Chuan
Xu, Kaihao
Zhu, Haidong
Han, Xinwei
All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction
title All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction
title_full All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction
title_fullStr All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction
title_full_unstemmed All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction
title_short All-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction
title_sort all-in-one properties of an anticancer-covered airway stent for the prevention of malignant central airway obstruction
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503995/
https://www.ncbi.nlm.nih.gov/pubmed/37719298
http://dx.doi.org/10.1063/5.0157341
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