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Comprehensive Search for GPCR Compounds which Can Enhance MafA and/or PDX-1 Expression Levels Using a Small Molecule Compound Library

It has been shown that chronic hyperglycemia gradually decreases insulin biosynthesis and secretion which is accompanied by reduced expression of very important insulin gene transcription factors MafA and PDX-1. Such phenomena are well known as β-cell glucose toxicity. It has been shown that the dow...

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Detalles Bibliográficos
Autores principales:	Kaneto, Hideaki, Obata, Atsushi, Shimoda, Masashi, Kimura, Tomohiko, Obata, Yoshiyuki, Ikeda, Tomoko, Moriuchi, Saeko, Nakanishi, Shuhei, Mune, Tomoatsu, Kaku, Kohei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504048/ https://www.ncbi.nlm.nih.gov/pubmed/37720599 http://dx.doi.org/10.1155/2023/8803172

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