RNA interference targeting ANGPTL3 for triglyceride and cholesterol lowering: phase 1 basket trial cohorts

Elevated triglycerides and non-high-density lipoprotein cholesterol (HDL-C) are risk factors for atherosclerotic cardiovascular disease (ASCVD). ARO-ANG3 is an RNA interference therapy that targets angiopoietin-like protein 3 (ANGPTL3), a regulator of lipoprotein metabolism. This first-in-human, pha...

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Detalles Bibliográficos
Autores principales: Watts, Gerald F., Schwabe, Christian, Scott, Russell, Gladding, Patrick A., Sullivan, David, Baker, John, Clifton, Peter, Hamilton, James, Given, Bruce, Melquist, Stacey, Zhou, Rong, Chang, Ting, San Martin, Javier, Gaudet, Daniel, Goldberg, Ira J., Knowles, Joshua W., Hegele, Robert A., Ballantyne, Christie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504078/
https://www.ncbi.nlm.nih.gov/pubmed/37626170
http://dx.doi.org/10.1038/s41591-023-02494-2

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