Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

Immunoparalysis is a compensatory and persistent anti-inflammatory response to trauma, sepsis or another serious insult, which increases the risk of opportunistic infections, morbidity and mortality. Here, we show that in cultured primary human monocytes, interleukin-4 (IL4) inhibits acute inflammat...

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Detalles Bibliográficos
Autores principales: Schrijver, David P., Röring, Rutger J., Deckers, Jeroen, de Dreu, Anne, Toner, Yohana C., Prevot, Geoffrey, Priem, Bram, Munitz, Jazz, Nugraha, Eveline G., van Elsas, Yuri, Azzun, Anthony, Anbergen, Tom, Groh, Laszlo A., Becker, Anouk M. D., Pérez-Medina, Carlos, Oosterwijk, Roderick S., Novakovic, Boris, Moorlag, Simone J. C. F. M., Jansen, Aron, Pickkers, Peter, Kox, Matthijs, Beldman, Thijs J., Kluza, Ewelina, van Leent, Mandy M. T., Teunissen, Abraham J. P., van der Meel, Roy, Fayad, Zahi A., Joosten, Leo A. B., Fisher, Edward A., Merkx, Maarten, Netea, Mihai G., Mulder, Willem J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504080/
https://www.ncbi.nlm.nih.gov/pubmed/37291433
http://dx.doi.org/10.1038/s41551-023-01050-0

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