Mechanisms of antigen escape from BCMA- or GPRC5D-targeted immunotherapies in multiple myeloma

B cell maturation antigen (BCMA) target loss is considered to be a rare event that mediates multiple myeloma (MM) resistance to anti-BCMA chimeric antigen receptor T cell (CAR T) or bispecific T cell engager (TCE) therapies. Emerging data report that downregulation of G-protein-coupled receptor fami...

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Detalles Bibliográficos
Autores principales: Lee, Holly, Ahn, Sungwoo, Maity, Ranjan, Leblay, Noemie, Ziccheddu, Bachisio, Truger, Marietta, Chojnacka, Monika, Cirrincione, Anthony, Durante, Michael, Tilmont, Remi, Barakat, Elie, Poorebrahim, Mansour, Sinha, Sarthak, McIntyre, John, M.Y. Chan, Angela, Wilson, Holly, Kyman, Shari, Krishnan, Amrita, Landgren, Ola, Walter, Wencke, Meggendorfer, Manja, Haferlach, Claudia, Haferlach, Torsten, Einsele, Hermann, Kortüm, Martin K., Knop, Stefan, Alberge, Jean Baptiste, Rosenwald, Andreas, Keats, Jonathan J., Rasche, Leo, Maura, Francesco, Neri, Paola, Bahlis, Nizar J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504087/
https://www.ncbi.nlm.nih.gov/pubmed/37653344
http://dx.doi.org/10.1038/s41591-023-02491-5

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