Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex

Turner syndrome (TS) leads to a characteristic phenotype, including premature ovarian insufficiency and infertility. Ovarian tissue cryopreservation (OTC) is becoming an established fertility preservation strategy for both pre- and post-pubertal females and may offer the chance of having a biologica...

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Autores principales: Dunlop, CE, Jack, SA, Telfer, EE, Zahra, S., Anderson, RA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Fertility Preservation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504145/
https://www.ncbi.nlm.nih.gov/pubmed/37566317
http://dx.doi.org/10.1007/s10815-023-02905-w
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author Dunlop, CE
Jack, SA
Telfer, EE
Zahra, S.
Anderson, RA
author_facet Dunlop, CE
Jack, SA
Telfer, EE
Zahra, S.
Anderson, RA
author_sort Dunlop, CE
collection PubMed
description Turner syndrome (TS) leads to a characteristic phenotype, including premature ovarian insufficiency and infertility. Ovarian tissue cryopreservation (OTC) is becoming an established fertility preservation strategy for both pre- and post-pubertal females and may offer the chance of having a biological family to selected patients with TS. To date, women with TS have had ovarian tissue cryopreserved but there are few reports of autologous re-implantation and none of pregnancy. We herein report, to our knowledge, the first clinical pregnancy in a patient with TS, conceived naturally following re-implantation of cryopreserved ovarian tissue which had been removed soon after spontaneous puberty. This provides proof of concept for OTC as a means of fertility preservation in TS.
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spelling pubmed-105041452023-09-17 Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex Dunlop, CE Jack, SA Telfer, EE Zahra, S. Anderson, RA J Assist Reprod Genet Fertility Preservation Turner syndrome (TS) leads to a characteristic phenotype, including premature ovarian insufficiency and infertility. Ovarian tissue cryopreservation (OTC) is becoming an established fertility preservation strategy for both pre- and post-pubertal females and may offer the chance of having a biological family to selected patients with TS. To date, women with TS have had ovarian tissue cryopreserved but there are few reports of autologous re-implantation and none of pregnancy. We herein report, to our knowledge, the first clinical pregnancy in a patient with TS, conceived naturally following re-implantation of cryopreserved ovarian tissue which had been removed soon after spontaneous puberty. This provides proof of concept for OTC as a means of fertility preservation in TS. Springer US 2023-08-11 2023-10 /pmc/articles/PMC10504145/ /pubmed/37566317 http://dx.doi.org/10.1007/s10815-023-02905-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Fertility Preservation
Dunlop, CE
Jack, SA
Telfer, EE
Zahra, S.
Anderson, RA
Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex
title Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex
title_full Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex
title_fullStr Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex
title_full_unstemmed Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex
title_short Clinical pregnancy in Turner syndrome following re-implantation of cryopreserved ovarian cortex
title_sort clinical pregnancy in turner syndrome following re-implantation of cryopreserved ovarian cortex
topic Fertility Preservation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504145/
https://www.ncbi.nlm.nih.gov/pubmed/37566317
http://dx.doi.org/10.1007/s10815-023-02905-w
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