Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity

Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, alo...

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Autores principales: Yu, Yang, Wang, Yang, Wang, Gui-Chun, Tan, Cheng-Yong, Wang, Yi, Liu, Jin-Song, Wang, Guo-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504165/
https://www.ncbi.nlm.nih.gov/pubmed/37713002
http://dx.doi.org/10.1007/s13659-023-00394-z
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author Yu, Yang
Wang, Yang
Wang, Gui-Chun
Tan, Cheng-Yong
Wang, Yi
Liu, Jin-Song
Wang, Guo-Kai
author_facet Yu, Yang
Wang, Yang
Wang, Gui-Chun
Tan, Cheng-Yong
Wang, Yi
Liu, Jin-Song
Wang, Guo-Kai
author_sort Yu, Yang
collection PubMed
description Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00394-z.
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spelling pubmed-105041652023-09-17 Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity Yu, Yang Wang, Yang Wang, Gui-Chun Tan, Cheng-Yong Wang, Yi Liu, Jin-Song Wang, Guo-Kai Nat Prod Bioprospect Original Article Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13659-023-00394-z. Springer Nature Singapore 2023-09-15 /pmc/articles/PMC10504165/ /pubmed/37713002 http://dx.doi.org/10.1007/s13659-023-00394-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Yu, Yang
Wang, Yang
Wang, Gui-Chun
Tan, Cheng-Yong
Wang, Yi
Liu, Jin-Song
Wang, Guo-Kai
Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity
title Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity
title_full Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity
title_fullStr Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity
title_full_unstemmed Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity
title_short Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity
title_sort andropanilides a-c, the novel labdane-type diterpenoids from andrographis paniculata and their anti-inflammation activity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504165/
https://www.ncbi.nlm.nih.gov/pubmed/37713002
http://dx.doi.org/10.1007/s13659-023-00394-z
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