Species-specific lipophilicities of fluorinated diketones in complex equilibria systems and their potential as multifaceted reversible covalent warheads

Combined molecular, physicochemical and chemical properties of electrophilic warheads can be applied to create covalent drugs with diverse facets. Here we study these properties in fluorinated diketones (FDKs) and their multicomponent equilibrium systems in the presence of protic nucleophiles, revea...

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Detalles Bibliográficos
Autores principales: Columbus, Ishay, Ghindes-Azaria, Lee, Herzog, Ido Michael, Blum, Eliav, Parvari, Galit, Eichen, Yoav, Cohen, Yoram, Gershonov, Eytan, Drug, Eyal, Saphier, Sigal, Elias, Shlomi, Smolkin, Boris, Zafrani, Yossi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504258/
https://www.ncbi.nlm.nih.gov/pubmed/37715018
http://dx.doi.org/10.1038/s42004-023-01004-2

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