Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment

The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target antigen heterogeneity or antigen loss of target cancer cells, an...

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Detalles Bibliográficos
Autores principales: Wang, Yufeng, Drum, David L., Sun, Ruochuan, Zhang, Yida, Chen, Feng, Sun, Fengfei, Dal, Emre, Yu, Ling, Jia, Jingyu, Arya, Shahrzad, Jia, Lin, Fan, Song, Isakoff, Steven J., Kehlmann, Allison M., Dotti, Gianpietro, Liu, Fubao, Zheng, Hui, Ferrone, Cristina R., Taghian, Alphonse G., DeLeo, Albert B., Ventin, Marco, Cattaneo, Giulia, Li, Yongxiang, Jounaidi, Youssef, Huang, Peigen, Maccalli, Cristina, Zhang, Hanyu, Wang, Cheng, Yang, Jibing, Boland, Genevieve M., Sadreyev, Ruslan I., Wong, LaiPing, Ferrone, Soldano, Wang, Xinhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504259/
https://www.ncbi.nlm.nih.gov/pubmed/37714830
http://dx.doi.org/10.1038/s41467-023-41282-x

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