Cargando…

Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism

Mostrar otras versiones (1)

Cilia are hairlike protrusions that project from the surface of eukaryotic cells and play key roles in cell signaling and motility. Ciliary motility is regulated by the conserved nexin-dynein regulatory complex (N-DRC), which links adjacent doublet microtubules and regulates and coordinates the acti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghanaeian, Avrin, Majhi, Sumita, McCafferty, Caitlyn L., Nami, Babak, Black, Corbin S., Yang, Shun Kai, Legal, Thibault, Papoulas, Ophelia, Janowska, Martyna, Valente-Paterno, Melissa, Marcotte, Edward M., Wloga, Dorota, Bui, Khanh Huy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504270/ https://www.ncbi.nlm.nih.gov/pubmed/37714832 http://dx.doi.org/10.1038/s41467-023-41480-7

Ejemplares similares

Integrated modeling of the Nexin-dynein regulatory complex reveals its regulatory mechanism
por: Ghanaeian, Avrin, et al.
Publicado: (2023)

Native doublet microtubules from Tetrahymena thermophila reveal the importance of outer junction proteins
por: Kubo, Shintaroh, et al.
Publicado: (2023)

An amino acid-resolution interactome for motile cilia illuminates the structure and function of ciliopathy protein complexes
por: McCafferty, Caitlyn L., et al.
Publicado: (2023)

Detailed structural and biochemical characterization of the nexin-dynein regulatory complex
por: Oda, Toshiyuki, et al.
Publicado: (2015)

The dynein regulatory complex is the nexin link and a major regulatory node in cilia and flagella
por: Heuser, Thomas, et al.
Publicado: (2009)

Does AlphaFold2 model proteins’ intracellular conformations? An experimental test using cross-linking mass spectrometry of endogenous ciliary proteins
por: McCafferty, Caitlyn L., et al.
Publicado: (2023)

Epigenetic Silencing of HER2 Expression during Epithelial-Mesenchymal Transition Leads to Trastuzumab Resistance in Breast Cancer
por: Nami, Babak, et al.
Publicado: (2021)

Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that connects radial spoke 3 to dynein g and the nexin link
por: Bazan, Rafał, et al.
Publicado: (2021)

Electrostatic interaction between polyglutamylated tubulin and the nexin–dynein regulatory complex regulates flagellar motility
por: Kubo, Tomohiro, et al.
Publicado: (2017)

DRC3 is an assembly adapter of the nexin-dynein regulatory complex functional components during spermatogenesis in humans and mice
por: Zhou, Shushu, et al.
Publicado: (2023)

Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex
por: McCafferty, Caitlyn L, et al.
Publicado: (2022)

In vivo imaging reveals independent intraflagellar transport of the nexin–dynein regulatory complex subunits DRC2 and DRC4
por: Saravanan, Sahana, et al.
Publicado: (2023)

Regulatory mechanisms of the dynein-2 motility by post-translational modification revealed by MD simulation
por: Kubo, Shintaroh, et al.
Publicado: (2023)

Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice
por: Morohoshi, Akane, et al.
Publicado: (2020)

DRC2/CCDC65 is a central hub for assembly of the nexin–dynein regulatory complex and other regulators of ciliary and flagellar motility
por: Bower, Raqual, et al.
Publicado: (2018)

Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins
por: Lee, Chanjae, et al.
Publicado: (2020)

Sculpting the dynein regulatory complex
por: deCathelineau, Aimee
Publicado: (2009)

Simplified geometric representations of protein structures identify complementary interaction interfaces
por: McCafferty, Caitlyn L., et al.
Publicado: (2020)

Improving integrative 3D modeling into low‐ to medium‐resolution electron microscopy structures with evolutionary couplings
por: McCafferty, Caitlyn L., et al.
Publicado: (2021)

Structural Biology in the Multi-Omics Era
por: McCafferty, Caitlyn L., et al.
Publicado: (2020)

The inner dynein arms I2 interact with a "dynein regulatory complex" in Chlamydomonas flagella
Publicado: (1992)

The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein
por: Liu, Xinglei, et al.
Publicado: (2020)

Mutations in the "dynein regulatory complex" alter the ATP-insensitive binding sites for inner arm dyneins in Chlamydomonas axonemes
Publicado: (1994)

Components of a "dynein regulatory complex" are located at the junction between the radial spokes and the dynein arms in Chlamydomonas flagella
Publicado: (1994)

In silico Mapping of Protein Unfolding Mutations for Inherited Disease
por: McCafferty, Caitlyn L., et al.
Publicado: (2016)

Dataset of eye disease-related proteins analyzed using the unfolding mutation screen
por: McCafferty, Caitlyn L., et al.
Publicado: (2016)

Global computational mutagenesis provides a critical stability framework in protein structures
por: McCafferty, Caitlyn L., et al.
Publicado: (2017)

Correction: Global computational mutagenesis provides a critical stability framework in protein structures
por: McCafferty, Caitlyn L., et al.
Publicado: (2018)

Regulatory ATPase Sites of Cytoplasmic Dynein Affect Processivity and Force Generation
por: Cho, Carol, et al.
Publicado: (2008)

Protein nonadditive expression and solubility contribute to heterosis in Arabidopsis hybrids and allotetraploids
por: June, Viviana, et al.
Publicado: (2023)

Caprin Controls Follicle Stem Cell Fate in the Drosophila Ovary
por: Reich, John, et al.
Publicado: (2012)

Controlled Measurement and Comparative Analysis of Cellular Components in E. coli Reveals Broad Regulatory Changes in Response to Glucose Starvation
por: Houser, John R., et al.
Publicado: (2015)

Polarity and asymmetry in the arrangement of dynein and related structures in the Chlamydomonas axoneme
por: Bui, Khanh Huy, et al.
Publicado: (2012)

Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders
por: Jaarsma, Dick, et al.
Publicado: (2015)

Sorting Nexins in Protein Homeostasis
por: Hanley, Sara E., et al.
Publicado: (2020)

Molecular architecture of inner dynein arms in situ in Chlamydomonas reinhardtii flagella
por: Bui, Khanh Huy, et al.
Publicado: (2008)

Asymmetry of inner dynein arms and inter-doublet links in Chlamydomonas flagella
por: Bui, Khanh Huy, et al.
Publicado: (2009)

Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility
por: Kobayashi, Takuya, et al.
Publicado: (2017)

Sequential accumulation of dynein and its regulatory proteins at the spindle region in the Caenorhabditis elegans embryo
por: Torisawa, Takayuki, et al.
Publicado: (2022)

Peter Cullen: Nexins have it sorted
por: Sedwick, Caitlin
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_cergg4t8ojh33njked0ro8q5vp