Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity

Inhibition of T cell infiltration dampens antitumor immunity and causes resistance to immune checkpoint blockade (ICB) therapy. By in vivo CRISPR screening in B16F10 melanoma in female mice, here we report that loss of melanocortin-1 receptor (MC1R) in melanoma cells activates antitumor T cell respo...

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Detalles Bibliográficos
Autores principales: Cui, Yazhong, Miao, Yang, Cao, Longzhi, Guo, Lifang, Cui, Yue, Yan, Chuanzhe, Zeng, Zhi, Xu, Mo, Han, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504282/
https://www.ncbi.nlm.nih.gov/pubmed/37714844
http://dx.doi.org/10.1038/s41467-023-41101-3

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