Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation

A repeat expansion in the C9orf72 (C9) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate single nucleus transcriptomics (snRNA-seq) and epigenomics (snATAC-seq) in postmortem motor and frontal cortices from C9-ALS, C9-...

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Detalles Bibliográficos
Autores principales: Li, Junhao, Jaiswal, Manoj K., Chien, Jo-Fan, Kozlenkov, Alexey, Jung, Jinyoung, Zhou, Ping, Gardashli, Mahammad, Pregent, Luc J., Engelberg-Cook, Erica, Dickson, Dennis W., Belzil, Veronique V., Mukamel, Eran A., Dracheva, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504300/
https://www.ncbi.nlm.nih.gov/pubmed/37714849
http://dx.doi.org/10.1038/s41467-023-41033-y

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